User:Ona Ambrozaite/Sandbox 1
From Proteopedia
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== General Function == | == General Function == | ||
| + | Trichosurin is a protein from the milk whey of the common brushtail possum ''Trichosurus vulpecula'' <ref>PMID: 17685895</ref>. It is a lipocalin, which is an extracellular protein (17–25 kDa) that can bind and transport small lipophilic molecules <ref>PMID: 17685895</ref>. | ||
== Structure == | == Structure == | ||
| + | Trichosurin follows the general lipocalin fold pattern, with eight-stranded anti-parallel β-barrel, and the structure then forms a dimer with another identical β-barrel <ref>PMID: 17685895</ref>. | ||
== Structure and Function == | == Structure and Function == | ||
| - | + | The binding site is found in the centre of the β-barrel and can be occupied by water and isopropanol molecules from the corresponding crystallization medium <ref>PMID: 17685895</ref>. The protein was also crystallized with 2-naphthol and 4-ethylphenol that were bound in the centre of the β-barrel. The presence of such phenolic compounds provides clues to the function of trichosurin- . | |
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== Evolutionarily Related Proteins == | == Evolutionarily Related Proteins == | ||
== Relevance == | == Relevance == | ||
| + | Trichosurin is an important marsupial milk protein, is highly conserved across metatherians. The opossum, | ||
== Available Structures == | == Available Structures == | ||
Revision as of 23:50, 4 March 2020
Trichosurin
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