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3j9p

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Revision as of 18:15, 10 April 2020

Structure of the TRPA1 ion channel determined by electron cryo-microscopy

3j9p, resolution 4.24Å

Structural highlights

3j9p is a 4 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:	malE, ANKTM1, TRPA1 (HUMAN)
Experimental data:	Check to display Experimental Data
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[MALE_ECOLI] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.

Publication Abstract from PubMed

The TRPA1 ion channel (also known as the wasabi receptor) is a detector of noxious chemical agents encountered in our environment or produced endogenously during tissue injury or drug metabolism. These include a broad class of electrophiles that activate the channel through covalent protein modification. TRPA1 antagonists hold potential for treating neurogenic inflammatory conditions provoked or exacerbated by irritant exposure. Despite compelling reasons to understand TRPA1 function, structural mechanisms underlying channel regulation remain obscure. Here we use single-particle electron cryo- microscopy to determine the structure of full-length human TRPA1 to approximately 4 A resolution in the presence of pharmacophores, including a potent antagonist. Several unexpected features are revealed, including an extensive coiled-coil assembly domain stabilized by polyphosphate co-factors and a highly integrated nexus that converges on an unpredicted transient receptor potential (TRP)-like allosteric domain. These findings provide new insights into the mechanisms of TRPA1 regulation, and establish a blueprint for structure-based design of analgesic and anti-inflammatory agents.

Structure of the TRPA1 ion channel suggests regulatory mechanisms.,Paulsen CE, Armache JP, Gao Y, Cheng Y, Julius D Nature. 2015 Apr 8. doi: 10.1038/nature14367. PMID:25855297^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Paulsen CE, Armache JP, Gao Y, Cheng Y, Julius D. Structure of the TRPA1 ion channel suggests regulatory mechanisms. Nature. 2015 Apr 8. doi: 10.1038/nature14367. PMID:25855297 doi:http://dx.doi.org/10.1038/nature14367

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3j9p"

@@ Line 3: / Line 3: @@
 <SX load='3j9p' size='340' side='right' viewer='molstar' caption='[[3j9p]], [[Resolution|resolution]] 4.24&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[3j9p]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J9P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3J9P FirstGlance]. <br>
+<table><tr><td colspan='2'>[[3j9p]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J9P OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3J9P FirstGlance]. <br>
 </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">malE, ANKTM1, TRPA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3j9p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j9p OCA], [http://pdbe.org/3j9p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3j9p RCSB], [http://www.ebi.ac.uk/pdbsum/3j9p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3j9p ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3j9p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j9p OCA], [http://pdbe.org/3j9p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3j9p RCSB], [http://www.ebi.ac.uk/pdbsum/3j9p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3j9p ProSAT]</span></td></tr>
 </table>
 == Function ==

3j9p

From Proteopedia

Revision as of 18:15, 10 April 2020

Structure of the TRPA1 ion channel determined by electron cryo-microscopy

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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