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6jcs

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Revision as of 02:05, 11 April 2020

AAV5 in complex with AAVR

6jcs, resolution 3.18Å

Structural highlights

6jcs is a 2 chain structure with sequence from Adeno-associated virus - 5 and Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:	KIAA0319L, AAVR, KIAA1837, PP791 (HUMAN)
Experimental data:	Check to display Experimental Data
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

[K319L_HUMAN] Systemic lupus erythematosus;Limited cutaneous systemic sclerosis.

Function

[K319L_HUMAN] Possible role in axon guidance through interaction with RTN4R.^[1]

Publication Abstract from PubMed

Adeno-associated virus (AAV) receptor (AAVR) is an essential receptor for the entry of multiple AAV serotypes with divergent rules; however, the mechanism remains unclear. Here, we determine the structures of the AAV1-AAVR and AAV5-AAVR complexes, revealing the molecular details by which PKD1 recognizes AAV5 and PKD2 is solely engaged with AAV1. PKD2 lies on the plateau region of the AAV1 capsid. However, the AAV5-AAVR interface is strikingly different, in which PKD1 is bound at the opposite side of the spike of the AAV5 capsid than the PKD2-interacting region of AAV1. Residues in strands F/G and the CD loop of PKD1 interact directly with AAV5, whereas residues in strands B/C/E and the BC loop of PKD2 make contact with AAV1. These findings further the understanding of the distinct mechanisms by which AAVR recognizes various AAV serotypes and provide an example of a single receptor engaging multiple viral serotypes with divergent rules.

Divergent engagements between adeno-associated viruses with their cellular receptor AAVR.,Zhang R, Xu G, Cao L, Sun Z, He Y, Cui M, Sun Y, Li S, Li H, Qin L, Hu M, Yuan Z, Rao Z, Ding W, Rao Z, Lou Z Nat Commun. 2019 Aug 21;10(1):3760. doi: 10.1038/s41467-019-11668-x. PMID:31434885^[2]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Poon MW, Tsang WH, Chan SO, Li HM, Ng HK, Waye MM. Dyslexia-associated kiaa0319-like protein interacts with axon guidance receptor nogo receptor 1. Cell Mol Neurobiol. 2011 Jan;31(1):27-35. doi: 10.1007/s10571-010-9549-1. Epub, 2010 Aug 10. PMID:20697954 doi:http://dx.doi.org/10.1007/s10571-010-9549-1
↑ Zhang R, Xu G, Cao L, Sun Z, He Y, Cui M, Sun Y, Li S, Li H, Qin L, Hu M, Yuan Z, Rao Z, Ding W, Rao Z, Lou Z. Divergent engagements between adeno-associated viruses with their cellular receptor AAVR. Nat Commun. 2019 Aug 21;10(1):3760. doi: 10.1038/s41467-019-11668-x. PMID:31434885 doi:http://dx.doi.org/10.1038/s41467-019-11668-x

1 Structural highlights
2 Disease
3 Function
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6jcs"

@@ Line 3: / Line 3: @@
 <SX load='6jcs' size='340' side='right' viewer='molstar' caption='[[6jcs]], [[Resolution|resolution]] 3.18&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[6jcs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Adeno-associated_virus_-_5 Adeno-associated virus - 5] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JCS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JCS FirstGlance]. <br>
+<table><tr><td colspan='2'>[[6jcs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Adeno-associated_virus_-_5 Adeno-associated virus - 5] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JCS OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6JCS FirstGlance]. <br>
 </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KIAA0319L, AAVR, KIAA1837, PP791 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6jcs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jcs OCA], [http://pdbe.org/6jcs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jcs RCSB], [http://www.ebi.ac.uk/pdbsum/6jcs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jcs ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6jcs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jcs OCA], [http://pdbe.org/6jcs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jcs RCSB], [http://www.ebi.ac.uk/pdbsum/6jcs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jcs ProSAT]</span></td></tr>
 </table>
 == Disease ==

6jcs

From Proteopedia

Revision as of 02:05, 11 April 2020

AAV5 in complex with AAVR

Structural highlights

Disease

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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