6jpf

From Proteopedia

(Difference between revisions)

Revision as of 02:13, 11 April 2020

Structure of atOSCA1.1 channel at 3.52A

6jpf, resolution 3.52Å

Structural highlights

6jpf is a 2 chain structure with sequence from Arath. This structure supersedes the now removed PDB entry 5yd1. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:	OSCA1, At4g04340, T19B17.6 (ARATH)
Experimental data:	Check to display Experimental Data
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[CSCL5_ARATH] Acts as a hyperosmolarity-gated non-selective cation channel that permeates Ca(2+) ions. Shows the following permeability sequence: K(+) > Ba(2+) = Ca(2+) > Na(+) = Mg(2+) = Cs(+).^[1]

Publication Abstract from PubMed

Mechanosensitive ion channels convert mechanical stimuli into a flow of ions. These channels are widely distributed from bacteria to higher plants and humans, and are involved in many crucial physiological processes. Here we show that two members of the OSCA protein family in Arabidopsis thaliana, namely AtOSCA1.1 and AtOSCA3.1, belong to a new class of mechanosensitive ion channels. We solve the structure of the AtOSCA1.1 channel at 3.5-A resolution and AtOSCA3.1 at 4.8-A resolution by cryo-electron microscopy. OSCA channels are symmetric dimers that are mediated by cytosolic inter-subunit interactions. Strikingly, they have structural similarity to the mammalian TMEM16 family proteins. Our structural analysis accompanied with electrophysiological studies identifies the ion permeation pathway within each subunit and suggests a conformational change model for activation.

Structure of the mechanosensitive OSCA channels.,Zhang M, Wang D, Kang Y, Wu JX, Yao F, Pan C, Yan Z, Song C, Chen L Nat Struct Mol Biol. 2018 Sep;25(9):850-858. doi: 10.1038/s41594-018-0117-6. Epub, 2018 Sep 6. PMID:30190597^[2]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Yuan F, Yang H, Xue Y, Kong D, Ye R, Li C, Zhang J, Theprungsirikul L, Shrift T, Krichilsky B, Johnson DM, Swift GB, He Y, Siedow JN, Pei ZM. OSCA1 mediates osmotic-stress-evoked Ca2+ increases vital for osmosensing in Arabidopsis. Nature. 2014 Oct 16;514(7522):367-71. doi: 10.1038/nature13593. Epub 2014 Aug 27. PMID:25162526 doi:http://dx.doi.org/10.1038/nature13593
↑ Zhang M, Wang D, Kang Y, Wu JX, Yao F, Pan C, Yan Z, Song C, Chen L. Structure of the mechanosensitive OSCA channels. Nat Struct Mol Biol. 2018 Sep;25(9):850-858. doi: 10.1038/s41594-018-0117-6. Epub, 2018 Sep 6. PMID:30190597 doi:http://dx.doi.org/10.1038/s41594-018-0117-6

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6jpf"

@@ Line 3: / Line 3: @@
 <SX load='6jpf' size='340' side='right' viewer='molstar' caption='[[6jpf]], [[Resolution|resolution]] 3.52&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[6jpf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5yd1 5yd1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JPF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JPF FirstGlance]. <br>
+<table><tr><td colspan='2'>[[6jpf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5yd1 5yd1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JPF OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6JPF FirstGlance]. <br>
 </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">OSCA1, At4g04340, T19B17.6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6jpf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jpf OCA], [http://pdbe.org/6jpf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jpf RCSB], [http://www.ebi.ac.uk/pdbsum/6jpf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jpf ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6jpf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jpf OCA], [http://pdbe.org/6jpf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jpf RCSB], [http://www.ebi.ac.uk/pdbsum/6jpf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jpf ProSAT]</span></td></tr>
 </table>
 == Function ==

6jpf

From Proteopedia

Revision as of 02:13, 11 April 2020

Structure of atOSCA1.1 channel at 3.52A

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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