1aq1

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[[Image:1aq1.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1aq1| PDB=1aq1 | SCENE= }}
{{STRUCTURE_1aq1| PDB=1aq1 | SCENE= }}
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'''HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR STAUROSPORINE'''
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===HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR STAUROSPORINE===
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==Overview==
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Staurosporine exhibits nanomolar IC50 values against a wide range of protein kinases. The structure of a CDK2 staurosporine complex explains the tight binding of this inhibitor, and suggests features to be exploited in the design of specific inhibitors of CDKs.
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The line below this paragraph, {{ABSTRACT_PUBMED_9334743}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9334743 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9334743}}
==About this Structure==
==About this Structure==
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[[Category: Protein kinase]]
[[Category: Protein kinase]]
[[Category: Staurosporine]]
[[Category: Staurosporine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:34:07 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:23:09 2008''

Revision as of 14:23, 30 June 2008

Template:STRUCTURE 1aq1

HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR STAUROSPORINE

Template:ABSTRACT PUBMED 9334743

About this Structure

1AQ1 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2., Lawrie AM, Noble ME, Tunnah P, Brown NR, Johnson LN, Endicott JA, Nat Struct Biol. 1997 Oct;4(10):796-801. PMID:9334743

Page seeded by OCA on Mon Jun 30 17:23:09 2008

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