6vaa
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of the Fanconi Anemia ID complex bound to ICL DNA== | |
| - | + | <StructureSection load='6vaa' size='340' side='right'caption='[[6vaa]], [[Resolution|resolution]] 3.35Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6vaa]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VAA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6VAA FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6vaa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vaa OCA], [http://pdbe.org/6vaa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vaa RCSB], [http://www.ebi.ac.uk/pdbsum/6vaa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vaa ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/FACD2_HUMAN FACD2_HUMAN]] Fanconi anemia. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/FACD2_HUMAN FACD2_HUMAN]] Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress. Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress. Promotes BRCA2/FANCD1 loading onto damaged chromatin. May also be involved in B-cell immunoglobulin isotype switching.<ref>PMID:11239453</ref> <ref>PMID:11239454</ref> <ref>PMID:12086603</ref> <ref>PMID:12239151</ref> <ref>PMID:14517836</ref> <ref>PMID:15115758</ref> <ref>PMID:15314022</ref> <ref>PMID:15377654</ref> <ref>PMID:15454491</ref> <ref>PMID:15650050</ref> <ref>PMID:15661754</ref> <ref>PMID:15671039</ref> <ref>PMID:19465921</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Pavletich, N P]] | ||
| + | [[Category: Dna binding protein]] | ||
| + | [[Category: Dna binding protein-dna complex]] | ||
| + | [[Category: Dna repair]] | ||
Revision as of 10:00, 18 March 2020
Structure of the Fanconi Anemia ID complex bound to ICL DNA
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