2duk
From Proteopedia
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<StructureSection load='2duk' size='340' side='right'caption='[[2duk]], [[Resolution|resolution]] 2.62Å' scene=''> | <StructureSection load='2duk' size='340' side='right'caption='[[2duk]], [[Resolution|resolution]] 2.62Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2duk]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2duk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DUK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DUK FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2duk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2duk OCA], [https://pdbe.org/2duk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2duk RCSB], [https://www.ebi.ac.uk/pdbsum/2duk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2duk ProSAT], [https://www.topsan.org/Proteins/RSGI/2duk TOPSAN]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/NUDT4_MOUSE NUDT4_MOUSE]] Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), PP-InsP4 and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphate Ap6A, but not Ap5A. The major reaction products are ADP and p4a from Ap6A. Also able to hydrolyze 5-phosphoribose 1-diphosphate (By similarity). |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Revision as of 17:16, 15 December 2021
Crystal structure of MS0616
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