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5bqg

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<StructureSection load='5bqg' size='340' side='right'caption='[[5bqg]], [[Resolution|resolution]] 1.44&Aring;' scene=''>
<StructureSection load='5bqg' size='340' side='right'caption='[[5bqg]], [[Resolution|resolution]] 1.44&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5bqg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BQG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BQG FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5bqg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BQG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5BQG FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4UJ:2-CHLORO-N-(4-PHENYL-1,3-THIAZOL-2-YL)BENZAMIDE'>4UJ</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=JZR:HEXYL+BETA-D-GLUCOPYRANOSIDE'>JZR</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4UJ:2-CHLORO-N-(4-PHENYL-1,3-THIAZOL-2-YL)BENZAMIDE'>4UJ</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=JZR:HEXYL+BETA-D-GLUCOPYRANOSIDE'>JZR</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PTGES, MGST1L1, MPGES1, PGES, PIG12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5bqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bqg OCA], [https://pdbe.org/5bqg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5bqg RCSB], [https://www.ebi.ac.uk/pdbsum/5bqg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5bqg ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-E_synthase Prostaglandin-E synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.99.3 5.3.99.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bqg OCA], [http://pdbe.org/5bqg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5bqg RCSB], [http://www.ebi.ac.uk/pdbsum/5bqg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5bqg ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PTGES_HUMAN PTGES_HUMAN]] Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2).<ref>PMID:18682561</ref>
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[https://www.uniprot.org/uniprot/PTGES_HUMAN PTGES_HUMAN] Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2).<ref>PMID:18682561</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Prostaglandin-E synthase]]
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[[Category: Antonysamy S]]
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[[Category: Antonysamy, S]]
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[[Category: Fisher MJ]]
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[[Category: Fisher, M J]]
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[[Category: Kuklish SL]]
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[[Category: Kuklish, S L]]
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[[Category: Luz JG]]
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[[Category: Luz, J G]]
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[[Category: Schiffler MA]]
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[[Category: Schiffler, M A]]
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[[Category: Enzyme]]
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[[Category: Integral membrane protein]]
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[[Category: Isomerase-isomerase inhibitor complex]]
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[[Category: Mpges-1]]
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Revision as of 06:03, 7 June 2023

Crystal Structure of mPGES-1 Bound to an Inhibitor

PDB ID 5bqg

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