Tryptophan synthase
From Proteopedia
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</StructureSection> | </StructureSection> | ||
| - | ==3D structures of tryptophan synthase== | ||
| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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| - | *'''Tryptophan synthase α subunit''' | ||
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| - | **[[1rd5]] - TrpS α subunit – corn<br /> | ||
| - | **[[3vnd]] - TrpS α subunit – ''Shewanella frigidimarina''<br /> | ||
| - | **[[3tha]] - TrpS α subunit – ''Campylobacter jejuni''<br /> | ||
| - | **[[3nav]] - TrpS α subunit – ''Vibrio cholerae''<br /> | ||
| - | **[[1geq]] - PfTrpS α subunit - ''Pyrococcus furiosus''<br /> | ||
| - | **[[2dzp]], [[2dzs]], [[2dzt]], [[2dzu]], [[2dzv]], [[2dzw]], [[2dzx]], [[2e09]] - PfTrpS α subunit (mutant)<br /> | ||
| - | **[[1ujp]] - TtTrpS α subunit <br /> | ||
| - | **[[1v7y]], [[1wq5]], [[1xc4]] - EcTrpS α subunit <br /> | ||
| - | **[[1xcf]] - EcTrpS α subunit (mutant)<br /> | ||
| - | **[[2ekc]] - TrpS α subunit – ''Aquifex aeolicus''<br /> | ||
| - | **[[5kmy]], [[5k9x]], [[6oky]] - TrpS α subunit – ''Legionella pneumophila''<br /> | ||
| - | **[[5n2p]] - SsTrpS α subunit – ''Sulfolobus solfataricus''<br /> | ||
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| - | *Tryptophan synthase α binary complex | ||
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| - | **[[1wxj]] - TtTrpS α subunit + indole propanol phosphate<br /> | ||
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| - | *'''Tryptophan synthase β subunit''' | ||
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| - | **[[1x1q]] - TtTrpS β subunit – ''Thermus thermophilus''<br /> | ||
| - | **[[2dh6]] - EcTrpS β subunit - ''Escherichia coli''<br /> | ||
| - | **[[2o2e]], [[2o2j]] - MtTrpS β subunit – ''Mycobacterium tuberculosis''<br /> | ||
| - | **[[1v8z]] - PfTrpS β1 subunit <br /> | ||
| - | **[[4neg]] - TrpS β subunit – ''Bacillus anthracis''<br /> | ||
| - | **[[4qys]], [[6hte]] - SsTrpS β2 subunit<br /> | ||
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| - | *Tryptophan synthase β complex | ||
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| - | **[[2dh5]] - EcTrpS β subunit + PLP<br /> | ||
| - | **[[6eqn]] - SsTrpS β2 subunit + PLP<br /> | ||
| - | **[[5dvz]] - PfTrpS β1 subunit + PLP derivative <br /> | ||
| - | **[[6am7]], [[6amc]], [[6cuv]] - PfTrpS β1 subunit (mutant) + PLP derivative <br /> | ||
| - | **[[5dw0]] - PfTrpS β1 subunit + Ser derivative <br /> | ||
| - | **[[5dw3]] - PfTrpS β1 subunit + PLP derivative + Trp<br /> | ||
| - | **[[6am8]], [[6ami]] - PfTrpS β1 subunit (mutant) + PLP derivative + Trp<br /> | ||
| - | **[[5t6m]] - PfTrpS β1 subunit + PLP derivative + Trp derivative<br /> | ||
| - | **[[5vm5]] - PfTrpS β1 subunit + PLP derivative + Ser derivative<br /> | ||
| - | **[[5ixj]] - PfTrpS β1 subunit + PLP derivative + Thr<br /> | ||
| - | **[[6am9]], [[6amh]] - PfTrpS β1 subunit (mutant) + PLP-Ser derivative <br /> | ||
| - | **[[6cut]] - PfTrpS β1 subunit (mutant) + Trp analog <br /> | ||
| - | **[[6cuz]] - PfTrpS β1 subunit (mutant) + PLP derivative + ethylserine<br /> | ||
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| - | *'''Tryptophan synthase α+β subunits''' | ||
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| - | **[[1wdw]] - PfTrpS α + β subunits <br /> | ||
| - | **[[6hul]] - SsTrpS α + β subunits <br /> | ||
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| - | *Tryptophan synthase α+β binary complex | ||
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| - | **[[1ttp]], [[1ttq]], [[1bks]], [[2wsy]], [[1kfk]] - StTrpS α + β + PLP – ''Salmonella typhimurium''<br /> | ||
| - | **[[1k7x]], [[2j9z]] - StTrpS α + β (mutant) + PLP<br /> | ||
| - | **[[3pr2]], [[4hn4]], [[4hpj]], [[4hpx]], [[4ht3]], [[4kkx]] - StTrpS α + β + inhibitor<br /> | ||
| - | **[[1kfj]] - StTrpS α + β + pyridoxal-serine-monophsphate<br /> | ||
| - | **[[1a5a]], [[1k8x]] - StTrpS α (mutant) + β + PLP<br /> | ||
| - | **[[1kfe]] - StTrpS α (mutant) + β + pyridoxal-serine-monophsphate<br /> | ||
| - | **[[6o1h]], [[6dzo]], [[6duc]], [[6d0v]], [[6c73]] - StTrpS α + β (mutant) + inhibitor<br /> | ||
| - | **[[2j9y]] - StTrpS α + β (mutant) + enoic acid derivative<br /> | ||
| - | **[[2tys]] - StTrpS α (mutant) + β (mutant) + Trp derivative<br /> | ||
| - | **[[5kzm]] - TrpS α + β + PLP derivative – ''Francisella tularensis''<br /> | ||
| - | **[[5kin]] - TrpS α + β + PLP derivative – ''Streptococcus pneumoniae''<br /> | ||
| - | **[[5e0k]] - PfTrpS α + β + PLP derivative <br /> | ||
| - | **[[5ocw]], [[5tcg]], [[5tci]], [[5tcj]] - MtTrpS α + β + inhibitor<br /> | ||
| - | **[[5tcf]] - MtTrpS α + β + PLP derivative <br /> | ||
| - | **[[5tch]] - MtTrpS α + β (mutant) + PLP derivative <br /> | ||
| - | **[[5e0k]] - PfTrpS α + β + PLP derivative <br /> | ||
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| - | *Tryptophan synthase α+β ternary complex with PLP and inhibitor | ||
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| - | **[[1a50]], [[1cw2]], [[1c9d]], [[1cx9]], [[1c8v]], [[1c29]], [[2cle]], [[2clh]], [[2cli]], [[2clk]], [[2cll]], [[2clm]], [[2clo]], [[2clf]], [[5bw6]], [[4zqc]], [[4y6g]], [[4xug]], [[4wx2]], [[5bw6]] - StTrpS α + β + inhibitor + PLP<br /> | ||
| - | **[[5cgq]] - StTrpS α + β + inhibitor + PLP + Trp<br /> | ||
| - | **[[1fuy]] - StTrpS α + β (mutant) + inhibitor + PLP<br /> | ||
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| - | *Tryptophan synthase α+β ternary complex with PLP and IGP derivatives | ||
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| - | **[[1a5b]], [[1kfb]] - StTrpS α (mutant) + β + IGP + PLP<br /> | ||
| - | **[[1k8z]] - StTrpS α + β (mutant) + IGP derivative + PLP<br /> | ||
| - | **[[1kfc]] - StTrpS α (mutant) + β + IGP derivative + PLP<br /> | ||
| - | **[[1k3u]], [[1k7e]], [[1k7f]] - StTrpS α + β + IGP derivative + PLP<br /> | ||
| - | **[[1qoq]], [[2rh9]], [[2rhg]] - StTrpS α + β + IGP + PLP<br /> | ||
| - | **[[1qop]] - StTrpS α + β + IGP analog + PLP<br /> | ||
| - | **[[2trs]], [[1beu]] - StTrpS α (mutant) + β (mutant) + pyridoxal-serine-monophsphate + IGP analog | ||
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| - | *Tryptophan synthase α+β ternary complex with PLP and G3P derivatives | ||
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| - | **[[1wbj]] - StTrpS α + β + G3P + PLP<br /> | ||
| - | **[[2j9x]] - StTrpS α + β + G3P + acrylic acid derivative<br /> | ||
| - | **[[1k8y]] - StTrpS α + β (mutant) + G3P derivative + PLP<br /> | ||
| - | **[[1tjp]] - StTrpS α + β + G3P derivative + PLP<br /> | ||
| - | **[[2tsy]] - StTrpS α (mutant) + β (mutant) + pyridoxal-serine-monophsphate + G3P | ||
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| - | **[[1ubs]] - StTrpS α (mutant) + β (mutant) + serine + PLP<br /> | ||
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| - | *Tryptophan synthase α+β quaternary complex | ||
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| - | **[[1a5s]] - StTrpS α + β + serine + inhibitor + PLP<br /> | ||
| - | **[[5cgq]] - StTrpS α + β + Trp + inhibitor + PLP<br /> | ||
| - | **[[3cep]] - StTrpS α + β + G3P + indoline + PLP<br /> | ||
| - | **[[6uap]], [[6ub9]], [[6dwe]], [[6e9p]] - MtTrpS α + β + malonate + inhibitor + PLP derivative<br /> | ||
| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 09:12, 11 March 2020
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References
- ↑ Miles EW. Tryptophan synthase: a multienzyme complex with an intramolecular tunnel. Chem Rec. 2001;1(2):140-51. PMID:11893063
- ↑ Shen H, Yang Y, Wang F, Zhang Y, Ye N, Xu S, Wang H. Characterization of the putative tryptophan synthase beta-subunit from Mycobacterium tuberculosis. Acta Biochim Biophys Sin (Shanghai). 2009 May;41(5):379-88. PMID:19430702
- ↑ Kulik V, Hartmann E, Weyand M, Frey M, Gierl A, Niks D, Dunn MF, Schlichting I. On the structural basis of the catalytic mechanism and the regulation of the alpha subunit of tryptophan synthase from Salmonella typhimurium and BX1 from maize, two evolutionarily related enzymes. J Mol Biol. 2005 Sep 23;352(3):608-20. PMID:16120446 doi:10.1016/j.jmb.2005.07.014
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