6uz8

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Current revision (13:12, 6 November 2024) (edit) (undo)
 
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<StructureSection load='6uz8' size='340' side='right'caption='[[6uz8]], [[Resolution|resolution]] 2.84&Aring;' scene=''>
<StructureSection load='6uz8' size='340' side='right'caption='[[6uz8]], [[Resolution|resolution]] 2.84&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6uz8]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UZ8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6UZ8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6uz8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UZ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6UZ8 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=R0D:(5-chloro-1H-spiro[indole-3,4-piperidin]-1-yl)[(2R)-2,3-dihydro-1,4-benzodioxin-2-yl]methanone'>R0D</scene>, <scene name='pdbligand=SBM:2-[[(2~{S})-2-decanoyloxy-3-dodecanoyloxy-propoxy]-oxidanyl-phosphoryl]oxyethyl-trimethyl-azanium'>SBM</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.84&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6uz8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6uz8 OCA], [http://pdbe.org/6uz8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6uz8 RCSB], [http://www.ebi.ac.uk/pdbsum/6uz8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6uz8 ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=R0D:(5-chloranylspiro[indole-3,4-piperidine]-1-yl)-[(3~{R})-2,3-dihydro-1,4-benzodioxin-3-yl]methanone'>R0D</scene>, <scene name='pdbligand=SBM:2-[[(2~{S})-2-decanoyloxy-3-dodecanoyloxy-propoxy]-oxidanyl-phosphoryl]oxyethyl-trimethyl-azanium'>SBM</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6uz8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6uz8 OCA], [https://pdbe.org/6uz8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6uz8 RCSB], [https://www.ebi.ac.uk/pdbsum/6uz8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6uz8 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/TRPC6_HUMAN TRPC6_HUMAN]] Familial idiopathic steroid-resistant nephrotic syndrome with focal segmental hyalinosis. The disease is caused by mutations affecting the gene represented in this entry.
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[https://www.uniprot.org/uniprot/TRPC6_HUMAN TRPC6_HUMAN] Familial idiopathic steroid-resistant nephrotic syndrome with focal segmental hyalinosis. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TRPC6_HUMAN TRPC6_HUMAN]] Thought to form a receptor-activated non-selective calcium permeant cation channel (PubMed:19936226, PubMed:23291369). Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C (PubMed:26892346). Seems not to be activated by intracellular calcium store depletion.<ref>PMID:19936226</ref> <ref>PMID:23291369</ref> <ref>PMID:26892346</ref>
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[https://www.uniprot.org/uniprot/TRPC6_HUMAN TRPC6_HUMAN] Thought to form a receptor-activated non-selective calcium permeant cation channel (PubMed:19936226, PubMed:23291369). Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C (PubMed:26892346). Seems not to be activated by intracellular calcium store depletion.<ref>PMID:19936226</ref> <ref>PMID:23291369</ref> <ref>PMID:26892346</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bai, Y]]
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[[Category: Bai Y]]
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[[Category: Chen, H]]
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[[Category: Chen H]]
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[[Category: Huang, X]]
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[[Category: Huang X]]
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[[Category: Yu, X]]
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[[Category: Yu X]]
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[[Category: Agonist]]
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[[Category: Transport protein]]
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[[Category: Trp channel]]
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Current revision

Cryo-EM structure of human TRPC6 in complex with agonist AM-0883

PDB ID 6uz8

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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