6vps

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Current revision (14:39, 6 March 2024) (edit) (undo)
 
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<StructureSection load='6vps' size='340' side='right'caption='[[6vps]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='6vps' size='340' side='right'caption='[[6vps]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6vps]] is a 9 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VPS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6VPS FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6vps]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VPS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6VPS FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6vps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vps OCA], [http://pdbe.org/6vps PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vps RCSB], [http://www.ebi.ac.uk/pdbsum/6vps PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vps ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6vps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vps OCA], [https://pdbe.org/6vps PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6vps RCSB], [https://www.ebi.ac.uk/pdbsum/6vps PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6vps ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ORB2_DROME ORB2_DROME]] Required in mushroom body gamma neurons for long-term memory in male courtship (PubMed:17965711, PubMed:23083740). Binds to mRNA 3'-UTRs (PubMed:20547833, PubMed:26638074, PubMed:24830287, PubMed:26095367). In its monomeric form, acts as a translational repressor of genes involved in neuronal growth, synapse formation and protein turnover (PubMed:20547833, PubMed:26638074). In its amyloid-like oligomeric form, acts as a translational activator (PubMed:26638074). The monomeric form reduces poly(A) tail length and destabilizes mRNA while the oligomeric form protects and elongates the poly(A) tail and stabilizes mRNA (PubMed:26638074). Isoform A is required for initial memory acquisition and, following subsequent late dopaminergic pathway activation, isoform A recruits isoform B into a complex to activate translation of CaMKII which is required for long-term memory consolidation (PubMed:26095367). Involved in asymmetric cell division in the central nervous system (PubMed:21900268). Required for the progression of spermatogenesis through meiosis and for sperm differentiation (PubMed:23209437). During sperm differentiation, required to asymmetrically localize and activate the translation of protein kinase aPKC mRNAs which is necessary for spermatid cyst polarization (PubMed:24830287). Also required during spermatid cyst polarization for localization and translation of its own mRNA (PubMed:24830287).<ref>PMID:17965711</ref> <ref>PMID:20547833</ref> <ref>PMID:21900268</ref> <ref>PMID:23083740</ref> <ref>PMID:23209437</ref> <ref>PMID:24830287</ref> <ref>PMID:26095367</ref> <ref>PMID:26638074</ref>
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[https://www.uniprot.org/uniprot/ORB2_DROME ORB2_DROME] Required in mushroom body gamma neurons for long-term memory in male courtship (PubMed:17965711, PubMed:23083740). Binds to mRNA 3'-UTRs (PubMed:20547833, PubMed:26638074, PubMed:24830287, PubMed:26095367). In its monomeric form, acts as a translational repressor of genes involved in neuronal growth, synapse formation and protein turnover (PubMed:20547833, PubMed:26638074). In its amyloid-like oligomeric form, acts as a translational activator (PubMed:26638074). The monomeric form reduces poly(A) tail length and destabilizes mRNA while the oligomeric form protects and elongates the poly(A) tail and stabilizes mRNA (PubMed:26638074). Isoform A is required for initial memory acquisition and, following subsequent late dopaminergic pathway activation, isoform A recruits isoform B into a complex to activate translation of CaMKII which is required for long-term memory consolidation (PubMed:26095367). Involved in asymmetric cell division in the central nervous system (PubMed:21900268). Required for the progression of spermatogenesis through meiosis and for sperm differentiation (PubMed:23209437). During sperm differentiation, required to asymmetrically localize and activate the translation of protein kinase aPKC mRNAs which is necessary for spermatid cyst polarization (PubMed:24830287). Also required during spermatid cyst polarization for localization and translation of its own mRNA (PubMed:24830287).<ref>PMID:17965711</ref> <ref>PMID:20547833</ref> <ref>PMID:21900268</ref> <ref>PMID:23083740</ref> <ref>PMID:23209437</ref> <ref>PMID:24830287</ref> <ref>PMID:26095367</ref> <ref>PMID:26638074</ref>
== References ==
== References ==
<references/>
<references/>
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[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Fitzpatrick, J A.J]]
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[[Category: Fitzpatrick JAJ]]
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[[Category: Hervas, R]]
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[[Category: Hervas R]]
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[[Category: Murzin, A G]]
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[[Category: Murzin AG]]
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[[Category: Park, Y]]
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[[Category: Park Y]]
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[[Category: Rau, M J]]
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[[Category: Rau MJ]]
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[[Category: Scheres, S H.W]]
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[[Category: Scheres SHW]]
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[[Category: Si, K]]
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[[Category: Si K]]
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[[Category: Zhang, W]]
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[[Category: Zhang W]]
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[[Category: Amyloid]]
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[[Category: Long-term memory]]
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[[Category: Prion-like]]
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[[Category: Protein fibril]]
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Current revision

Cryo-EM structure of the amyloid core of Drosophila Orb2 isolated from head

PDB ID 6vps

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OCA

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