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2era
From Proteopedia
(Difference between revisions)
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<StructureSection load='2era' size='340' side='right'caption='[[2era]], [[Resolution|resolution]] 1.81Å' scene=''> | <StructureSection load='2era' size='340' side='right'caption='[[2era]], [[Resolution|resolution]] 1.81Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2era]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2era]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Black-banded_sea_krait Black-banded sea krait]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ERA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ERA FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2era FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2era OCA], [https://pdbe.org/2era PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2era RCSB], [https://www.ebi.ac.uk/pdbsum/2era PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2era ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/NXSA_PSSEM NXSA_PSSEM]] Binds with high affinity to muscular nicotinic acetylcholine receptors (nAChRs) and with low affinity to neuronal alpha-7 nAChRs and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission. Produces peripheral paralysis by blocking neuromuscular transmission at the postsynaptic site. Blocks the extracellular increase of dopamine evoked by nicotine at 4.2 uM concentrations.<ref>PMID:9305882</ref> <ref>PMID:9840221</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Revision as of 15:41, 3 November 2021
RECOMBINANT ERABUTOXIN A, S8G MUTANT
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