This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


5bt4

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 3: Line 3:
<StructureSection load='5bt4' size='340' side='right'caption='[[5bt4]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
<StructureSection load='5bt4' size='340' side='right'caption='[[5bt4]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[5bt4]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BT4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BT4 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[5bt4]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BT4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5BT4 FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2LO:2-[2-(3-CHLORO-4-METHOXYPHENYL)ETHYL]-5-(3,5-DIMETHYL-1,2-OXAZOL-4-YL)-1-[(2S)-2-(MORPHOLIN-4-YL)PROPYL]-1H-BENZIMIDAZOLE'>2LO</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2LO:2-[2-(3-CHLORO-4-METHOXYPHENYL)ETHYL]-5-(3,5-DIMETHYL-1,2-OXAZOL-4-YL)-1-[(2S)-2-(MORPHOLIN-4-YL)PROPYL]-1H-BENZIMIDAZOLE'>2LO</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BRD4, HUNK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5bt4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bt4 OCA], [https://pdbe.org/5bt4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5bt4 RCSB], [https://www.ebi.ac.uk/pdbsum/5bt4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5bt4 ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bt4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bt4 OCA], [http://pdbe.org/5bt4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5bt4 RCSB], [http://www.ebi.ac.uk/pdbsum/5bt4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5bt4 ProSAT]</span></td></tr>
+
</table>
</table>
== Disease ==
== Disease ==
-
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
+
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
+
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
==See Also==
==See Also==
Line 19: Line 18:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Arrowsmith, C H]]
+
[[Category: Arrowsmith CH]]
-
[[Category: Bountra, C]]
+
[[Category: Bountra C]]
-
[[Category: Brennan, P E]]
+
[[Category: Brennan PE]]
-
[[Category: Delft, F von]]
+
[[Category: Edwards AM]]
-
[[Category: Edwards, A M]]
+
[[Category: Fedorov O]]
-
[[Category: Fedorov, O]]
+
[[Category: Hay D]]
-
[[Category: Hay, D]]
+
[[Category: Knapp S]]
-
[[Category: Knapp, S]]
+
[[Category: Krojer T]]
-
[[Category: Krojer, T]]
+
[[Category: Newman JA]]
-
[[Category: Newman, J A]]
+
[[Category: Nunez-Alonso G]]
-
[[Category: Nunez-Alonso, G]]
+
[[Category: Picaud S]]
-
[[Category: Picaud, S]]
+
[[Category: Tallant C]]
-
[[Category: Structural genomic]]
+
[[Category: Von Delft F]]
-
[[Category: Tallant, C]]
+
-
[[Category: Acetylation]]
+
-
[[Category: Chromatin and transcription regulator]]
+
-
[[Category: Sgc]]
+
-
[[Category: Transcription]]
+

Revision as of 06:07, 7 June 2023

Crystal structure of BRD4 first bromodomain in complex with SGC-CBP30 chemical probe

PDB ID 5bt4

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5bt4"
Personal tools