This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


5c2a

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:17, 7 June 2023) (edit) (undo)
 
Line 3: Line 3:
<StructureSection load='5c2a' size='340' side='right'caption='[[5c2a]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='5c2a' size='340' side='right'caption='[[5c2a]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[5c2a]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C2A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5C2A FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[5c2a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C2A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5C2A FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4Y2:6-CHLORO-2-CYCLOPROPYL-N-[(2,4-DIMETHYL-1,3-THIAZOL-5-YL)METHYL]-5-METHYLPYRIMIDIN-4-AMINE'>4Y2</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4Y2:6-CHLORO-2-CYCLOPROPYL-N-[(2,4-DIMETHYL-1,3-THIAZOL-5-YL)METHYL]-5-METHYLPYRIMIDIN-4-AMINE'>4Y2</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5c1w|5c1w]], [[5c28|5c28]], [[5c29|5c29]], [[5c2e|5c2e]], [[5c2h|5c2h]]</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5c2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c2a OCA], [https://pdbe.org/5c2a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5c2a RCSB], [https://www.ebi.ac.uk/pdbsum/5c2a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5c2a ProSAT]</span></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PDE10A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5c2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c2a OCA], [http://pdbe.org/5c2a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5c2a RCSB], [http://www.ebi.ac.uk/pdbsum/5c2a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5c2a ProSAT]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
+
[https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 27: Line 25:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Yan, Y]]
+
[[Category: Yan Y]]
-
[[Category: Complex]]
+
-
[[Category: Hydrolase-hydrolase inhibitor complex]]
+
-
[[Category: Inhibitor]]
+
-
[[Category: Phosphodiesterase]]
+

Current revision

PDE10 complexed with 6-chloro-2-cyclopropyl-N-[(2,4-dimethylthiazol-5-yl)methyl]-5-methyl-pyrimidin-4-amine

PDB ID 5c2a

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5c2a"
Personal tools