1kr7
From Proteopedia
(New page: 200px<br /> <applet load="1kr7" size="450" color="white" frame="true" align="right" spinBox="true" caption="1kr7, resolution 1.5Å" /> '''Crystal structure of...) |
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caption="1kr7, resolution 1.5Å" /> | caption="1kr7, resolution 1.5Å" /> | ||
'''Crystal structure of the nerve tissue mini-hemoglobin from the nemertean worm Cerebratulus lacteus'''<br /> | '''Crystal structure of the nerve tissue mini-hemoglobin from the nemertean worm Cerebratulus lacteus'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1KR7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Cerebratulus_lacteus Cerebratulus lacteus] with SO4, ACT, HEM and OXY as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 1KR7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Cerebratulus_lacteus Cerebratulus lacteus] with <scene name='pdbligand=SO4:'>SO4</scene>, <scene name='pdbligand=ACT:'>ACT</scene>, <scene name='pdbligand=HEM:'>HEM</scene> and <scene name='pdbligand=OXY:'>OXY</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KR7 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: protein cavities]] | [[Category: protein cavities]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:15:06 2008'' |
Revision as of 14:15, 15 February 2008
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Crystal structure of the nerve tissue mini-hemoglobin from the nemertean worm Cerebratulus lacteus
Overview
A very short hemoglobin (CerHb; 109 amino acids) binds O(2) cooperatively, in the nerve tissue of the nemertean worm Cerebratulus lacteus to sustain, neural activity during anoxia. Sequence analysis suggests that CerHb, tertiary structure may be unique among the known globin fold evolutionary, variants. The X-ray structure of oxygenated CerHb (R factor 15.3%, at 1.5, A resolution) displays deletion of the globin N-terminal A helix, an, extended GH region, a very short H helix, and heme solvent shielding based, on specific aromatic residues. The heme-bound O(2) is stabilized by, hydrogen bonds to the distal TyrB10-GlnE7 pair. Ligand access to heme may, take place through a wide protein matrix tunnel connecting the distal site, to a surface cleft located between the E and H helices.
About this Structure
1KR7 is a Single protein structure of sequence from Cerebratulus lacteus with , , and as ligands. Full crystallographic information is available from OCA.
Reference
The 109 residue nerve tissue minihemoglobin from Cerebratulus lacteus highlights striking structural plasticity of the alpha-helical globin fold., Pesce A, Nardini M, Dewilde S, Geuens E, Yamauchi K, Ascenzi P, Riggs AF, Moens L, Bolognesi M, Structure. 2002 May;10(5):725-35. PMID:12015154
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Categories: Cerebratulus lacteus | Single protein | Ascenzi, P. | Bolognesi, M. | Dewilde, S. | Geuens, E. | Moens, L. | Nardini, M. | Pesce, A. | Riggs, A.F. | Yamauchi, k. | ACT | HEM | OXY | SO4 | Mini-hemoglobin | Nerve tissue | Oxygen transport | Protein cavities
