1atp

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{{STRUCTURE_1atp| PDB=1atp | SCENE= }}
{{STRUCTURE_1atp| PDB=1atp | SCENE= }}
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'''2.2 ANGSTROM REFINED CRYSTAL STRUCTURE OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH MNATP AND A PEPTIDE INHIBITOR'''
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===2.2 ANGSTROM REFINED CRYSTAL STRUCTURE OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH MNATP AND A PEPTIDE INHIBITOR===
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==Overview==
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. The crystal structure of a ternary complex containing the catalytic subunit of cAMP-dependent protein kinase, ATP and a 20-residue inhibitor peptide was refined at a resolution of 2.2 A to an R value of 0.177. In order to identify the metal binding sites, the crystals, originally grown in the presence of low concentrations of Mg(2+), were soaked in Mn(2+). Two Mn(2+) ions were identified using an anomalous Fourier map. One Mn(2+) ion bridges the gamma- and beta-phosphates and interacts with Asp184 and two water molecules. The second Mn(2+) ion interacts with the side chains of Asn171 and Asp l84 as well as with a water molecule. Modeling a serine into the P site of the inhibitor peptide suggests a mechanism for phosphotransfer.
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(as it appears on PubMed at http://www.pubmed.gov), where 15299527 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15299527}}
==About this Structure==
==About this Structure==
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[[Category: Xuong, N H.]]
[[Category: Xuong, N H.]]
[[Category: Zheng, J.]]
[[Category: Zheng, J.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:34:32 2008''

Revision as of 14:34, 30 June 2008

Image:1atp.png

Template:STRUCTURE 1atp

2.2 ANGSTROM REFINED CRYSTAL STRUCTURE OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH MNATP AND A PEPTIDE INHIBITOR

Template:ABSTRACT PUBMED 15299527

About this Structure

1ATP is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

2.2 A refined crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MnATP and a peptide inhibitor., Zheng J, Trafny EA, Knighton DR, Xuong NH, Taylor SS, Ten Eyck LF, Sowadski JM, Acta Crystallogr D Biol Crystallogr. 1993 May 1;49(Pt 3):362-5. PMID:15299527

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