Sandbox Reserved 1606

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==Introduction==
==Introduction==
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The [https://en.wikipedia.org/wiki/ABCG2 ABCG2 multidrug transporter] is part of the ATP-binding cassette (ABC) transporter family. Also know as the breast cancer resistance protein (BCRP), ABCG2 has physiological roles in various tissue cells including the mammary gland and the blood-brain, bloodtestis, and maternal-fetal barriers.<ref name="Taylor"/>
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The [https://en.wikipedia.org/wiki/ABCG2 ABCG2 multidrug transporter] is a membrane protein from the ATP-binding cassette (ABC) transporter family, specifically the G-subfamily. Also know as the breast cancer resistance protein (BCRP), ABCG2 has physiological roles in various tissue cells including the mammary gland and the blood-brain, bloodtestis, and maternal-fetal barriers.<ref name="Taylor"/> ABCG2 protects cells by exporting xenobiotic molecules out of the cell using ATP hydrolysis. ABCG2 also affects the pharmacokinetics of many drugs and contributes to multidrug resistance.<ref name="Manolaridis"/>
== Function ==
== Function ==
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Transports xenobiotic molecules out of the cell (molecules that shouldn't be there) to protect cellular tissue
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Transports xenobiotic molecules out of the cell (molecules that shouldn't be there) to protect cellular tissue (expand a bit/maybe combine intro and function?)
== Structural highlights ==
== Structural highlights ==
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===ATP Bound and Unbound Conformations===
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===Overall 3D Structure===
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[[Image:ABC Unbound.png|300 px|left|thumb|FIGURE LEGEND]] [[Image:ABC Bound.png|300 px|right|thumb|FIGURE LEGEND]]
 
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===ATP Bound and Unbound Conformations===
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[[Image:bound and unbound.png|400 px|right|thumb|FIGURE LEGEND]]
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===Cavities and Lysine Plug===
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===Cavities and Lysine Plug===
 
==Disease==
==Disease==
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== References ==
== References ==
<ref name="Taylor">PMID:28554189</ref>
<ref name="Taylor">PMID:28554189</ref>
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<ref name="Manolaridis">PMID:30405239</ref>
<references/>
<references/>
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==Student Contributors===
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==Student Contributors==

Revision as of 20:34, 23 March 2020

This Sandbox is Reserved from Jan 13 through September 1, 2020 for use in the course CH462 Biochemistry II taught by R. Jeremy Johnson at the Butler University, Indianapolis, USA. This reservation includes Sandbox Reserved 1598 through Sandbox Reserved 1627.
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ABCG2 Multidrug Transporter

Caption for this structure

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References

[1] [2]

  1. ↑ 1.0 1.1 1.2 Taylor NMI, Manolaridis I, Jackson SM, Kowal J, Stahlberg H, Locher KP. Structure of the human multidrug transporter ABCG2. Nature. 2017 Jun 22;546(7659):504-509. doi: 10.1038/nature22345. Epub 2017 May, 29. PMID:28554189 doi:http://dx.doi.org/10.1038/nature22345
  2. ↑ 2.0 2.1 Manolaridis I, Jackson SM, Taylor NMI, Kowal J, Stahlberg H, Locher KP. Cryo-EM structures of a human ABCG2 mutant trapped in ATP-bound and substrate-bound states. Nature. 2018 Nov;563(7731):426-430. doi: 10.1038/s41586-018-0680-3. Epub 2018 Nov, 7. PMID:30405239 doi:http://dx.doi.org/10.1038/s41586-018-0680-3

Student Contributors

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