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Contents 1 Introduction 2 Function 3 Structural highlights 3.1 Overall 3D Structure 3.2 ATP Bound and Unbound Conformations 3.3 Cavities and Lysine Plug 4 Disease 4.1 Cancer 4.2 ABCG2 as a Target for Inhibition

Introduction

The ABCG2 multidrug transporter is a membrane protein from the ATP-binding cassette (ABC) transporter family, specifically the G-subfamily. Also know as the breast cancer resistance protein (BCRP), ABCG2 has physiological roles in various tissue cells including the mammary gland and the blood-brain, blood-testis, and maternal-fetal barriers.^[1] ABCG2 protects cells by exporting xenobiotic molecules out of the cell using ATP hydrolysis. ABCG2 also affects the pharmacokinetics of many drugs and contributes to multidrug resistance.^[2]

Function

Transports xenobiotic molecules out of the cell (molecules that shouldn't be there) to protect cellular tissue (expand a bit/maybe combine intro and function?) maybe explain the general mechanism here?

Structural highlights

Overall 3D Structure

NBD - binding site for atp Homodimer

ATP Bound and Unbound Conformations

Cavities and Lysine Plug

Disease

Cancer

ABCG2 contributes to multidrug resistance in cancer cells by exporting anti-tumor drugs out of cells which is an obstacle in cancer treatment.^[1] brief description of the cancer genes listed in the papers (papers talk about how some cancers had more expression of abcg2 genes)

ABCG2 as a Target for Inhibition

Talk about how and why it would be a good target for the treatment of cancer

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