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User:Jaelyn M. Voyles/Sandbox 1
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== Function == | == Function == | ||
| - | ABCG2 transporters are usually seen in apical membranes found in the liver and kidneys in order to move xenobiotics (undesirables) out of the cells. They also excrete the vitamins riboflavin and biotin into breast milk. A xenobiotic will bind to the binding pocket of ABCG2 on the inside of the cell and ATP will move to bind | + | ABCG2 transporters are usually seen in apical membranes found in the liver and kidneys in order to move xenobiotics (undesirables) out of the cells. They also excrete the vitamins riboflavin and biotin into breast milk. A xenobiotic will bind to the binding pocket of ABCG2 on the inside of the cell and ATP will move to bind on each nucleotide binding domains. This causes ABCG2 to undergo a conformational change and pushes the xenobiotic through the channel and out of the cell. |
== Disease == | == Disease == | ||
Revision as of 13:47, 24 March 2020
ATP-Binding Cassette Super Family G Member 2, ABCG2
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