1aut

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{{STRUCTURE_1aut| PDB=1aut | SCENE= }}
{{STRUCTURE_1aut| PDB=1aut | SCENE= }}
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'''HUMAN ACTIVATED PROTEIN C'''
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===HUMAN ACTIVATED PROTEIN C===
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==Overview==
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The structure of the Gla-domainless form of the human anticoagulant enzyme activated protein C has been solved at 2.8 A resolution. The light chain is composed of two domains: an epidermal growth factor (EGF)-like domain modified by a large insert containing an additional disulfide, followed by a typical EGF-like domain. The arrangement of the long axis of these domains describes an angle of approximately 80 degrees. Disulfide linked to the light chain is the catalytic domain, which is generally trypsin-like but contains a large insertion loop at the edge of the active site, a third helical segment, a prominent cationic patch analogous to the anion binding exosite I of thrombin and a trypsin-like Ca[II] binding site. The arrangement of loops around the active site partially restricts access to the cleft. The S2 and S4 subsites are much more polar than in factor Xa and thrombin, and the S2 site is unrestricted. While quite open and exposed, the active site contains a prominent groove, the surface of which is very polar with evidence for binding sites on the primed side, in addition to those typical of the trypsin class found on the non-primed side.
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The line below this paragraph, {{ABSTRACT_PUBMED_9003757}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9003757 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9003757}}
==About this Structure==
==About this Structure==
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[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: Plasma calcium binding]]
[[Category: Plasma calcium binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:43:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:38:18 2008''

Revision as of 14:38, 30 June 2008

Image:1aut.png

Template:STRUCTURE 1aut

HUMAN ACTIVATED PROTEIN C

Template:ABSTRACT PUBMED 9003757

About this Structure

1AUT is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The 2.8 A crystal structure of Gla-domainless activated protein C., Mather T, Oganessyan V, Hof P, Huber R, Foundling S, Esmon C, Bode W, EMBO J. 1996 Dec 16;15(24):6822-31. PMID:9003757

Page seeded by OCA on Mon Jun 30 17:38:18 2008

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