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1av1

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[[Image:1av1.gif|left|200px]]
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{{STRUCTURE_1av1| PDB=1av1 | SCENE= }}
{{STRUCTURE_1av1| PDB=1av1 | SCENE= }}
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'''CRYSTAL STRUCTURE OF HUMAN APOLIPOPROTEIN A-I'''
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===CRYSTAL STRUCTURE OF HUMAN APOLIPOPROTEIN A-I===
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==Overview==
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The structure of truncated human apolipoprotein A-I (apo A-I), the major protein component of high density lipoprotein, has been determined at 4-A resolution. The crystals comprise residues 44-243 (exon 4) of apo A-I, a fragment that binds to lipid similarly to intact apo A-I and that retains the lipid-bound conformation even in the absence of lipid. The molecule consists almost entirely of a pseudo-continuous, amphipathic alpha-helix that is punctuated by kinks at regularly spaced proline residues; it adopts a shape similar to a horseshoe of dimensions 125 x 80 x 40 A. Four molecules in the asymmetric unit associate via their hydrophobic faces to form an antiparallel four-helix bundle with an elliptical ring shape. Based on this structure, we propose a model for the structure of apo A-I bound to high density lipoprotein.
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(as it appears on PubMed at http://www.pubmed.gov), where 9356442 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9356442}}
==About this Structure==
==About this Structure==
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[[Category: Lipid transport]]
[[Category: Lipid transport]]
[[Category: Lipoprotein]]
[[Category: Lipoprotein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:43:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:39:02 2008''

Revision as of 14:39, 30 June 2008

Image:1av1.png

Template:STRUCTURE 1av1

CRYSTAL STRUCTURE OF HUMAN APOLIPOPROTEIN A-I

Template:ABSTRACT PUBMED 9356442

About this Structure

1AV1 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of truncated human apolipoprotein A-I suggests a lipid-bound conformation., Borhani DW, Rogers DP, Engler JA, Brouillette CG, Proc Natl Acad Sci U S A. 1997 Nov 11;94(23):12291-6. PMID:9356442

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