5dlo

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Current revision (21:48, 28 June 2023) (edit) (undo)
 
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<StructureSection load='5dlo' size='340' side='right'caption='[[5dlo]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
<StructureSection load='5dlo' size='340' side='right'caption='[[5dlo]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5dlo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DLO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DLO FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5dlo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_phage_MS2 Escherichia phage MS2] and [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DLO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DLO FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.401&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DU:2-DEOXYURIDINE-5-MONOPHOSPHATE'>DU</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">mazF, SAHV_2053 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5dlo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dlo OCA], [https://pdbe.org/5dlo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5dlo RCSB], [https://www.ebi.ac.uk/pdbsum/5dlo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5dlo ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dlo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dlo OCA], [http://pdbe.org/5dlo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dlo RCSB], [http://www.ebi.ac.uk/pdbsum/5dlo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5dlo ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MAZF_STAA8 MAZF_STAA8] Toxic component of a type II toxin-antitoxin (TA) system. Ribosome-independent, sequence-specific endoribonuclease that cleaves mRNA, thus inhibiting protein synthesis and inducing bacterial stasis. It cuts between the first and nucleotides of 5'-UACAU-3' in single-stranded RNA. Neutralized by coexpression with cognate antitoxin MazE.[UniProtKB:A6QIR4]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Escherichia phage MS2]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Loris, R]]
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[[Category: Staphylococcus aureus]]
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[[Category: Zorzini, V]]
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[[Category: Loris R]]
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[[Category: Bacterial stress response]]
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[[Category: Zorzini V]]
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[[Category: Hydrolase]]
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[[Category: Mrna interferase]]
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[[Category: Persistence]]
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[[Category: Ribonuclease]]
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[[Category: Toxin-antitoxin]]
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Current revision

S. aureus MazF in complex with substrate analogue

PDB ID 5dlo

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