1av5

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{{STRUCTURE_1av5| PDB=1av5 | SCENE= }}
{{STRUCTURE_1av5| PDB=1av5 | SCENE= }}
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'''PKCI-SUBSTRATE ANALOG'''
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===PKCI-SUBSTRATE ANALOG===
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==Overview==
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The histidine triad (HIT) protein family is among the most ubiquitous and highly conserved in nature, but a biological activity has not yet been identified for any member of the HIT family. Fragile histidine triad protein (FHIT) and protein kinase C interacting protein (PKCI) were used in a structure-based approach to elucidate characteristics of in vivo ligands and reactions. Crystallographic structures of apo, substrate analog, pentacovalent transition-state analog, and product states of both enzymes reveal a catalytic mechanism and define substrate characteristics required for catalysis, thus unifying the HIT family as nucleotidyl hydrolases, transferases, or both. The approach described here may be useful in identifying structure-function relations between protein families identified through genomics.
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{{ABSTRACT_PUBMED_9323207}}
==About this Structure==
==About this Structure==
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[[Category: Pkci-1]]
[[Category: Pkci-1]]
[[Category: Protein kinase inhibitor]]
[[Category: Protein kinase inhibitor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:43:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:39:29 2008''

Revision as of 14:39, 30 June 2008

Image:1av5.png

Template:STRUCTURE 1av5

PKCI-SUBSTRATE ANALOG

Template:ABSTRACT PUBMED 9323207

About this Structure

1AV5 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure-based analysis of catalysis and substrate definition in the HIT protein family., Lima CD, Klein MG, Hendrickson WA, Science. 1997 Oct 10;278(5336):286-90. PMID:9323207

Page seeded by OCA on Mon Jun 30 17:39:29 2008

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