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5cg5

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<StructureSection load='5cg5' size='340' side='right'caption='[[5cg5]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
<StructureSection load='5cg5' size='340' side='right'caption='[[5cg5]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5cg5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CG5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CG5 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5cg5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CG5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CG5 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DOD:DEUTERATED+WATER'>DOD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=RIS:1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE+BIS-PHOSPHONIC+ACID'>RIS</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DOD:DEUTERATED+WATER'>DOD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=RIS:1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE+BIS-PHOSPHONIC+ACID'>RIS</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5cg6|5cg6]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cg5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cg5 OCA], [https://pdbe.org/5cg5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cg5 RCSB], [https://www.ebi.ac.uk/pdbsum/5cg5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cg5 ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FDPS, FPS, KIAA1293 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cg5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cg5 OCA], [http://pdbe.org/5cg5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cg5 RCSB], [http://www.ebi.ac.uk/pdbsum/5cg5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cg5 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN]] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
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[https://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Kusaka, K]]
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[[Category: Kusaka K]]
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[[Category: Mizuguchi, M]]
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[[Category: Mizuguchi M]]
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[[Category: Niimura, N]]
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[[Category: Niimura N]]
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[[Category: Ostermann, A]]
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[[Category: Ostermann A]]
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[[Category: Schrader, T E]]
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[[Category: Schrader TE]]
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[[Category: Tanaka, I]]
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[[Category: Tanaka I]]
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[[Category: Yokoyama, T]]
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[[Category: Yokoyama T]]
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[[Category: Bisphophonate]]
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[[Category: Inhibitor]]
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[[Category: Osteoprosis]]
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[[Category: Prenyl transferase]]
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[[Category: Transferase-transferase inhibotor complex]]
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Revision as of 12:03, 14 June 2023

Neutron crystal structure of human farnesyl pyrophosphate synthase in complex with risedronate

PDB ID 5cg5

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