WD repeat-containing protein
From Proteopedia
(Difference between revisions)
| Line 14: | Line 14: | ||
</StructureSection> | </StructureSection> | ||
| - | == 3D Structures of WD-repeat protein == | ||
| - | |||
| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | |||
| - | *WDR5 | ||
| - | |||
| - | **[[2gnq]], [[2h68]], [[2h14]], [[2h9l]] – hWDR5 – human<br /> | ||
| - | **[[3mxx]], [[3n0d]], [[3n0e]] – hWDR5 (mutant)<br /> | ||
| - | **[[3smr]], [[3ur4]], [[4ia9]], [[4qqe]], [[4ql1]], [[5eal]], [[5eam]], [[5eap]], [[5ear]] – hWDR5 + piperazine derivative<br /> | ||
| - | **[[6u5m]], [[6u5y]], [[6u6w]], [[6u80]], [[6u8b]], [[6u8l]], [[6u8o]] – hWDR5 + sulfonamide inhibitor<br /> | ||
| - | **[[6ufx]], [[6ucs]], [[6pg3]], [[6pg4]], [[6pg5]], [[6pg6]], [[6pg7]], [[6pg8]], [[6pg9]], [[6pga]], [[6pgb]], [[6pgc]], [[6pgd]], [[6pge]], [[6pgf]], [[5vfc]], [[6dar]], [[6das]], [[6d9x]], [[6dai]], [[6dak]], [[6e1z]], [[6e1y]], [[6e22]], [[6e23]] – hWDR5 + inhibitor<br /> | ||
| - | **[[2cnx]], [[2co0]], [[2h6k]], [[2h6n]], [[2h6q]], [[2h13]], [[2h9m]], [[2h9n]], [[2h9p]], [[2g99]], [[2g9a]], [[2o9k]], [[3psl]], [[4a7j]] – hWDR5 + histone H3 peptide<br /> | ||
| - | **[[4gm3]], [[4gm8]], [[4gm9]], [[4gmb]] – hWDR5 + peptide inhibitor<br /> | ||
| - | **[[2xl2]], [[2xl3]] – hWDR5 + retinoblastoma-binding protein 5 peptide<br /> | ||
| - | **[[4o45]] – hWDR5 + influenza NS1 C-terminal<br /> | ||
| - | **[[4cy1]] – hWDR5 + KAT8 regulatory NSL complex subunit 1+2 peptides<br /> | ||
| - | **[[4cy2]] – hWDR5 + KAT8 regulatory NSL complex subunit 1 peptide<br /> | ||
| - | **[[4y7r]] – hWDR5 + Myc MbIIIb peptide<br /> | ||
| - | **[[3eg6]], [[3emh]], [[3uvk]], [[3uvl]], [[3uvm]], [[3uvn]], [[3uvo]], [[4erq]], [[4ery]], [[4es0]], [[4esg]], [[4ewr]], [[5sxm]] – hWDR5 + MLL peptide<br /> | ||
| - | **[[4erz]] – hWDR5 + MLL4<br /> | ||
| - | **[[6kiv]], [[6kiz]], [[6kiu]], [[6kix]] – hWDR5 in MLL1-ubNCP complex - Cryo EM<br /> | ||
| - | **[[6kiw]] – hWDR5 in MLL3-ubNCP complex - Cryo EM<br /> | ||
| - | **[[6pww]], [[6pwv]] – hWDR5 + MLL1 + RbBP5 + histones - Cryo EM<br /> | ||
| - | **[[6byn]] – hWDR5 + monobody<br /> | ||
| - | **[[3p4f]] – hWDR5 + retinoblastoma-binding protein 5 peptide + MLL peptide<br /> | ||
| - | **[[6iam]] – hWDR5 + small ubiquitin-related modifier 5<br /> | ||
| - | |||
| - | *WDR9 | ||
| - | |||
| - | **[[2q2e]] – hWDR9 residues 1310-1430<br /> | ||
| - | |||
| - | *WDR12 | ||
| - | |||
| - | **[[6p0q]] – hWDR12 UBL domain residues 1-87<br /> | ||
| - | **[[6n31]] – hWDR12 residues 90-422<br /> | ||
| - | |||
| - | *WDR20 | ||
| - | |||
| - | **[[5k19]] – hWDR20<br /> | ||
| - | |||
| - | *WDR33 or pre-mRNA 3' end processing protein WDR33 | ||
| - | |||
| - | **[[6f9n]] – hWDR33 residues 35-410 + CPSF160<br /> | ||
| - | **[[6urg]] – hWDR33 + CPSF160 + CPSF30 + CPSF100 - Cryo EM<br /> | ||
| - | **[[6fbs]], [[6fuw]], [[6uro]] – hWDR33 + CPSF160 + CPSF30 + PAS motif - Cryo EM<br /> | ||
| - | |||
| - | *WDR48 | ||
| - | |||
| - | **[[5cvl]] – hWDR48 <br /> | ||
| - | **[[5l8e]] – hWDR48 + peptide<br /> | ||
| - | **[[5l8w]], [[5cvn]], [[5cvo]] – hWDR48 + ubiquitin + ubiquitin carboxyl-terminal hydrolase<br /> | ||
| - | **[[5k1a]], [[5k1b]] – hWDR48 + ubiquitin carboxyl-terminal hydrolase<br /> | ||
| - | **[[5k1c]], [[6jlq]] – hWDR48 + WDR20 + ubiquitin carboxyl-terminal hydrolase<br /> | ||
| - | |||
| - | *WDR60 | ||
| - | |||
| - | **[[6rlb]], [[6sc2]] – hWDR60 + WDR34 + dynein + O6-alkylguanine-DNA alkyktransferase - Cryo EM<br /> | ||
| - | |||
| - | *WDR61 | ||
| - | |||
| - | **[[3ow8]] – hWDR61<br /> | ||
| - | |||
| - | *WDR91 | ||
| - | |||
| - | **[[6vyc]] – hWDR91 residues 392-747<br /> | ||
| - | |||
| - | *WDR92 | ||
| - | |||
| - | **[[3i2n]] – hWDR92<br /> | ||
| - | |||
| - | *WDR SLP1 | ||
| - | |||
| - | **[[4aez]] – WDR + mitotic spindle checkpoint component mad2-mad3 - fission yeast <br /> | ||
| - | |||
| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 09:43, 28 March 2020
| |||||||||||
References
- ↑ Li D, Roberts R. WD-repeat proteins: structure characteristics, biological function, and their involvement in human diseases. Cell Mol Life Sci. 2001 Dec;58(14):2085-97. PMID:11814058
- ↑ Gan Q, Thiebaud P, Theze N, Jin L, Xu G, Grant P, Owens GK. WD repeat-containing protein 5, a ubiquitously expressed histone methyltransferase adaptor protein, regulates smooth muscle cell-selective gene activation through interaction with pituitary homeobox 2. J Biol Chem. 2011 Jun 17;286(24):21853-64. doi: 10.1074/jbc.M111.233098. Epub, 2011 Apr 28. PMID:21531708 doi:http://dx.doi.org/10.1074/jbc.M111.233098
- ↑ Tullio-Pelet A, Salomon R, Hadj-Rabia S, Mugnier C, de Laet MH, Chaouachi B, Bakiri F, Brottier P, Cattolico L, Penet C, Begeot M, Naville D, Nicolino M, Chaussain JL, Weissenbach J, Munnich A, Lyonnet S. Mutant WD-repeat protein in triple-A syndrome. Nat Genet. 2000 Nov;26(3):332-5. PMID:11062474 doi:http://dx.doi.org/10.1038/81642
- ↑ Schuetz A, Allali-Hassani A, Martin F, Loppnau P, Vedadi M, Bochkarev A, Plotnikov AN, Arrowsmith CH, Min J. Structural basis for molecular recognition and presentation of histone H3 by WDR5. EMBO J. 2006 Sep 20;25(18):4245-52. Epub 2006 Aug 31. PMID:16946699
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky
