1avp

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[[Image:1avp.gif|left|200px]]
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{{Seed}}
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[[Image:1avp.png|left|200px]]
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{{STRUCTURE_1avp| PDB=1avp | SCENE= }}
{{STRUCTURE_1avp| PDB=1avp | SCENE= }}
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'''STRUCTURE OF HUMAN ADENOVIRUS 2 PROTEINASE WITH ITS 11 AMINO ACID COFACTOR'''
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===STRUCTURE OF HUMAN ADENOVIRUS 2 PROTEINASE WITH ITS 11 AMINO ACID COFACTOR===
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==Overview==
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The three-dimensional structure of the human adenovirus-2 proteinase complexed with its 11 amino acid cofactor, pVIc, was determined at 2.6 A resolution by X-ray crystallographic analysis. The fold of this protein has not been seen before. However, it represents an example of either subtly divergent or powerfully convergent evolution, because the active site contains a Cys-His-Glu triplet and oxyanion hole in an arrangement similar to that in papain. Thus, the adenovirus proteinase represents a new, fifth group of enzymes that contain catalytic triads. pVIc, which extends a beta-sheet in the main chain, is distant from the active site, yet its binding increases the catalytic rate constant 300-fold for substrate hydrolysis. The structure reveals several potential targets for antiviral therapy.
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(as it appears on PubMed at http://www.pubmed.gov), where 8617222 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8617222}}
==About this Structure==
==About this Structure==
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[[Category: Thiol hydrolase]]
[[Category: Thiol hydrolase]]
[[Category: Viral proteinase]]
[[Category: Viral proteinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:44:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:42:08 2008''

Revision as of 14:42, 30 June 2008

Image:1avp.png

Template:STRUCTURE 1avp

STRUCTURE OF HUMAN ADENOVIRUS 2 PROTEINASE WITH ITS 11 AMINO ACID COFACTOR

Template:ABSTRACT PUBMED 8617222

About this Structure

1AVP is a Protein complex structure of sequences from Human adenovirus 2. Full crystallographic information is available from OCA.

Reference

Crystal structure of the human adenovirus proteinase with its 11 amino acid cofactor., Ding J, McGrath WJ, Sweet RM, Mangel WF, EMBO J. 1996 Apr 15;15(8):1778-83. PMID:8617222

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