1aw7

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1aw7.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1aw7.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1aw7| PDB=1aw7 | SCENE= }}
{{STRUCTURE_1aw7| PDB=1aw7 | SCENE= }}
-
'''Q136A MUTANT OF TOXIC SHOCK SYNDROME TOXIN-1 FROM S. AUREUS'''
+
===Q136A MUTANT OF TOXIC SHOCK SYNDROME TOXIN-1 FROM S. AUREUS===
-
==Overview==
+
<!--
-
The three-dimensional structures of five mutants of toxic shock syndrome toxin-1 (TSST-1) have been determined. These mutations are in the long central alpha helix and are useful in mapping portions of TSST-1 involved in superantigenicity and lethality. The T128A, H135A, Q139K, and I140T mutations appear to reduce superantigenicity by altering the properties of the T-cell receptor interaction surface. The Q136A mutation is at a largely buried site and causes a dramatic change in the conformation of the beta7-beta9 loop which covers the back of the central alpha helix. As this mutation has the unique ability to reduce the toxin's lethality in rabbits while retaining its superantigenicity, it raises the possibility that this rear loop mediates the ability of TSST-1 to induce lethality and suggests a route for producing nonlethal toxins for therapeutic development.
+
The line below this paragraph, {{ABSTRACT_PUBMED_9585531}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 9585531 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_9585531}}
==About this Structure==
==About this Structure==
Line 31: Line 35:
[[Category: Superantigen]]
[[Category: Superantigen]]
[[Category: Toxin]]
[[Category: Toxin]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:46:08 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:44:00 2008''

Revision as of 14:44, 30 June 2008

Image:1aw7.png

Template:STRUCTURE 1aw7

Q136A MUTANT OF TOXIC SHOCK SYNDROME TOXIN-1 FROM S. AUREUS

Template:ABSTRACT PUBMED 9585531

About this Structure

1AW7 is a Single protein structure of sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.

Reference

Structures of five mutants of toxic shock syndrome toxin-1 with reduced biological activity., Earhart CA, Mitchell DT, Murray DL, Pinheiro DM, Matsumura M, Schlievert PM, Ohlendorf DH, Biochemistry. 1998 May 19;37(20):7194-202. PMID:9585531

Page seeded by OCA on Mon Jun 30 17:44:00 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1aw7"
Personal tools