2h4c

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<StructureSection load='2h4c' size='340' side='right'caption='[[2h4c]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='2h4c' size='340' side='right'caption='[[2h4c]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2h4c]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Daboia_russellii_siamensis Daboia russellii siamensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H4C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2H4C FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2h4c]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Daboia_russellii_siamensis Daboia russellii siamensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H4C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2H4C FirstGlance]. <br>
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</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>
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</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2h4c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h4c OCA], [http://pdbe.org/2h4c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2h4c RCSB], [http://www.ebi.ac.uk/pdbsum/2h4c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2h4c ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2h4c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h4c OCA], [https://pdbe.org/2h4c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2h4c RCSB], [https://www.ebi.ac.uk/pdbsum/2h4c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2h4c ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PA2AA_DABSI PA2AA_DABSI]] Heterodimer (A and B chains): phospholipase A2 that acts as a presynaptic neurotoxin and shows a PLA2 activity of 1377 umol/min/mg. In vivo, induces edema and produces neurotoxic symptoms in mice. Also exhibits indirect hemolysis, a strong myonecrotic activity and cytotoxicity. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Monomer: Snake venom phospholipase A2 (PLA2) that shows a PLA2 activity of 578 umol/min/mg. [[http://www.uniprot.org/uniprot/PA2AB_DABSI PA2AB_DABSI]] Monomer: Snake venom phospholipase A2 (PLA2) that shows a high PLA2 activity (2110 umol/min/mg). Heterodimer (A and B chains): snake venom phospholipase A2 that shows a moderate PLA2 activity (1377 umol/min/mg). Acts as a presynaptic neurotoxin. In vivo, induces edema and produces neurotoxic symptoms in mice. It exhibits indirect hemolysis and a strong myonecrotic activity and is cytotoxic. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
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[[https://www.uniprot.org/uniprot/PA2AA_DABSI PA2AA_DABSI]] Heterodimer (A and B chains): phospholipase A2 that acts as a presynaptic neurotoxin and shows a PLA2 activity of 1377 umol/min/mg. In vivo, induces edema and produces neurotoxic symptoms in mice. Also exhibits indirect hemolysis, a strong myonecrotic activity and cytotoxicity. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Monomer: Snake venom phospholipase A2 (PLA2) that shows a PLA2 activity of 578 umol/min/mg. [[https://www.uniprot.org/uniprot/PA2AB_DABSI PA2AB_DABSI]] Monomer: Snake venom phospholipase A2 (PLA2) that shows a high PLA2 activity (2110 umol/min/mg). Heterodimer (A and B chains): snake venom phospholipase A2 that shows a moderate PLA2 activity (1377 umol/min/mg). Acts as a presynaptic neurotoxin. In vivo, induces edema and produces neurotoxic symptoms in mice. It exhibits indirect hemolysis and a strong myonecrotic activity and is cytotoxic. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]

Revision as of 11:05, 5 January 2022

Structure of Daboiatoxin (heterodimeric PLA2 venom)

PDB ID 2h4c

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