1aww

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[[Image:1aww.gif|left|200px]]
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{{STRUCTURE_1aww| PDB=1aww | SCENE= }}
{{STRUCTURE_1aww| PDB=1aww | SCENE= }}
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'''SH3 DOMAIN FROM BRUTON'S TYROSINE KINASE, NMR, 42 STRUCTURES'''
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===SH3 DOMAIN FROM BRUTON'S TYROSINE KINASE, NMR, 42 STRUCTURES===
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==Overview==
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X-linked agammaglobulinemia (XLA) is a heritable immunodeficiency caused by mutations in the gene coding for Bruton's tyrosine kinase (Btk). Btk belongs to the Tec family of tyrosine kinases. Each member of the family contains five regions and mutations causing XLA have been isolated in all five regions. We have determined the solution structure of the Src homology 3 (SH3) domain of Btk using two- and three-dimensional nuclear magnetic resonance (NMR) spectroscopy on natural abundance and 15N-labeled protein material. The structure determination is complemented by investigation of backbone dynamics based on 15N NMR relaxation. The Btk SH3 forms a well-defined structure and shows the typical SH3 topology of two short antiparallel beta-sheets packed almost perpendicular to each other in a sandwich-like fold. The N- and C-termini are more flexible as are peptide fragments in the RT and n-Src loops. The studied Btk SH3 fragment adopts two slowly interconverting conformations with a relative concentration ratio of 7:1. The overall fold of the minor form is similar to that of the major form, as judged on the basis of observed NOE connectivities and small chemical shift differences. A tryptophan (W251) ring flip is the favored mechanism for interconversion, although other possibilities cannot be excluded. The side chain of Y223, which becomes autophosphorylated upon activation of Btk, is exposed within the potential SH3 ligand binding site. Finally, we compare the present Btk SH3 structure with other SH3 structures.
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(as it appears on PubMed at http://www.pubmed.gov), where 9485443 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9485443}}
==About this Structure==
==About this Structure==
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1AWW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AWW OCA].
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1AWW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AWW OCA].
==Reference==
==Reference==
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[[Category: X-linked agammaglobulinemia]]
[[Category: X-linked agammaglobulinemia]]
[[Category: Xla]]
[[Category: Xla]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:47:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:45:59 2008''

Revision as of 14:46, 30 June 2008

Image:1aww.png

Template:STRUCTURE 1aww

SH3 DOMAIN FROM BRUTON'S TYROSINE KINASE, NMR, 42 STRUCTURES

Template:ABSTRACT PUBMED 9485443

About this Structure

1AWW is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure of the SH3 domain from Bruton's tyrosine kinase., Hansson H, Mattsson PT, Allard P, Haapaniemi P, Vihinen M, Smith CI, Hard T, Biochemistry. 1998 Mar 3;37(9):2912-24. PMID:9485443

Page seeded by OCA on Mon Jun 30 17:45:59 2008

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