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5d1x

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Current revision (10:18, 21 June 2023) (edit) (undo)
 
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<StructureSection load='5d1x' size='340' side='right'caption='[[5d1x]], [[Resolution|resolution]] 3.21&Aring;' scene=''>
<StructureSection load='5d1x' size='340' side='right'caption='[[5d1x]], [[Resolution|resolution]] 3.21&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5d1x]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Staa3 Staa3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D1X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5D1X FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5d1x]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_USA300 Staphylococcus aureus subsp. aureus USA300]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D1X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5D1X FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5d1q|5d1q]], [[5d1z|5d1z]]</td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5d1x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d1x OCA], [https://pdbe.org/5d1x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5d1x RCSB], [https://www.ebi.ac.uk/pdbsum/5d1x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5d1x ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">isdB, frpB, sasJ, sirH, SAUSA300_1028 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=367830 STAA3])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5d1x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d1x OCA], [http://pdbe.org/5d1x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5d1x RCSB], [http://www.ebi.ac.uk/pdbsum/5d1x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5d1x ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ISDB_STAA3 ISDB_STAA3]] Seems to function as the primary receptor for hemoglobin since its inactivation inhibits the ability of S.aureus to bind hemoglobin. Binds hemoglobin in a dose-dependent way. Required for S.aureus growth using hemoglobin as the sole iron source. Also required for virulence. IsdA and/or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity).
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[https://www.uniprot.org/uniprot/ISDB_STAA8 ISDB_STAA8] Cell wall-anchored surface receptor that extracts heme from oxidized metHb to enable growth on hemoglobin as a sole iron source. Rapidly extracts heme from hemoglobin and transfers it to IsdA or IsdC, which then relays it to the membrane transporter/IsdEF for internalization. Promotes also resistance to hydrogen peroxide and killing by neutrophils.[UniProtKB:A6QG30]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Staa3]]
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[[Category: Staphylococcus aureus subsp. aureus USA300]]
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[[Category: Deng, X]]
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[[Category: Deng X]]
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[[Category: Germline encoded]]
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[[Category: Immune system]]
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[[Category: Isdb]]
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[[Category: Neat2]]
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Current revision

IsdB NEAT2 bound by D4-30

PDB ID 5d1x

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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