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5d7c

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<StructureSection load='5d7c' size='340' side='right'caption='[[5d7c]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
<StructureSection load='5d7c' size='340' side='right'caption='[[5d7c]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5d7c]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D7C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5D7C FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5d7c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D7C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5D7C FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=57W:1-ETHYL-3-[1-(PYRIDIN-2-YL)-6-(PYRIDIN-3-YL)-1H-PYRROLO[3,2-B]PYRIDIN-3-YL]UREA'>57W</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=57W:1-ETHYL-3-[1-(PYRIDIN-2-YL)-6-(PYRIDIN-3-YL)-1H-PYRROLO[3,2-B]PYRIDIN-3-YL]UREA'>57W</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5cph|5cph]], [[5ctu|5ctu]], [[5ctw|5ctw]], [[5ctx|5ctx]], [[5cty|5cty]], [[5d6p|5d6p]], [[5d6q|5d6q]], [[5d7r|5d7r]], [[5d7d|5d7d]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5d7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d7c OCA], [https://pdbe.org/5d7c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5d7c RCSB], [https://www.ebi.ac.uk/pdbsum/5d7c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5d7c ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">gyrB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5d7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d7c OCA], [http://pdbe.org/5d7c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5d7c RCSB], [http://www.ebi.ac.uk/pdbsum/5d7c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5d7c ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GYRB_STAAU GYRB_STAAU]] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.[HAMAP-Rule:MF_01898]
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[https://www.uniprot.org/uniprot/GYRB_STAAU GYRB_STAAU] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.[HAMAP-Rule:MF_01898]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Andersen, O A]]
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[[Category: Staphylococcus aureus]]
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[[Category: Barker, J]]
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[[Category: Andersen OA]]
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[[Category: Cheng, R K]]
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[[Category: Barker J]]
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[[Category: Cross, J B]]
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[[Category: Cheng RK]]
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[[Category: Dolle, R E]]
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[[Category: Cross JB]]
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[[Category: Felicetti, B]]
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[[Category: Dolle RE]]
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[[Category: Kahmann, J]]
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[[Category: Felicetti B]]
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[[Category: Lippa, B]]
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[[Category: Kahmann J]]
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[[Category: Romero, J A.C]]
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[[Category: Lippa B]]
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[[Category: Ryan, M D]]
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[[Category: Romero JAC]]
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[[Category: Scheich, C]]
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[[Category: Ryan MD]]
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[[Category: Wood, M]]
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[[Category: Scheich C]]
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[[Category: Yang, Q]]
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[[Category: Wood M]]
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[[Category: Zhang, J]]
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[[Category: Yang Q]]
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[[Category: Dna gyrase]]
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[[Category: Zhang J]]
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[[Category: Gyrb]]
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[[Category: Isomerase-isomerase inhibitor complex]]
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[[Category: Ligand]]
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[[Category: Structure-based design]]
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Revision as of 10:24, 21 June 2023

Crystal structure of the ATP binding domain of S. aureus GyrB complexed with a ligand

PDB ID 5d7c

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