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5d7x

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<StructureSection load='5d7x' size='340' side='right'caption='[[5d7x]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
<StructureSection load='5d7x' size='340' side='right'caption='[[5d7x]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5d7x]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D7X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5D7X FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5d7x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D7X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5D7X FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=XZ8:4-(1-ACETYL-1H-INDOL-3-YL)-5-METHYL-1,2-DIHYDRO-3H-PYRAZOL-3-ONE'>XZ8</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=XZ8:4-(1-ACETYL-1H-INDOL-3-YL)-5-METHYL-1,2-DIHYDRO-3H-PYRAZOL-3-ONE'>XZ8</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BRPF1, BR140 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5d7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d7x OCA], [https://pdbe.org/5d7x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5d7x RCSB], [https://www.ebi.ac.uk/pdbsum/5d7x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5d7x ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5d7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d7x OCA], [http://pdbe.org/5d7x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5d7x RCSB], [http://www.ebi.ac.uk/pdbsum/5d7x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5d7x ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/BRPF1_HUMAN BRPF1_HUMAN]] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Positively regulates the transcription of RUNX1 and RUNX2.<ref>PMID:16387653</ref> <ref>PMID:18794358</ref>
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[https://www.uniprot.org/uniprot/BRPF1_HUMAN BRPF1_HUMAN] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Positively regulates the transcription of RUNX1 and RUNX2.<ref>PMID:16387653</ref> <ref>PMID:18794358</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5d7x" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5d7x" style="background-color:#fffaf0;"></div>
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==See Also==
 
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*[[Peregrin|Peregrin]]
 
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Caflisch, A]]
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[[Category: Caflisch A]]
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[[Category: Zhu, J]]
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[[Category: Zhu J]]
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[[Category: Dna binding protein]]
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[[Category: Inhibitor]]
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Revision as of 10:24, 21 June 2023

Crystal structure of the human BRPF1 bromodomain in complex with XZ08

PDB ID 5d7x

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