Condensin
From Proteopedia
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== Function == | == Function == | ||
| - | '''Condensin''' or '''structural maintenance of chromosome protein''' (SMC) is required for correctly package and divide the cell's genome. SMC uses ATP to affect conformational changes in DNA, to correct DNA compaction, organization and segregation<ref>PMID:28181049</ref>. SMC exhibits the ability to super-coil DNA<ref>PMID:23218009</ref>. SMC of ''E. coli'' is named '''MukB''' or '''Chromosome partition protein A'''. SMC is found in species from bacteria to human. SMC and cohesin which share structural similarities, are essential for separting the genome into daughter cells during cell division. SMC reorganizes chromsomes into their compact mitotic structure while cohesin glues replicated sister chromatids together until they split at anaphase<ref>PMID:12838344</ref>. | + | '''Condensin''' or '''structural maintenance of chromosome protein''' (SMC) is required for correctly package and divide the cell's genome. SMC uses ATP to affect conformational changes in DNA, to correct DNA compaction, organization and segregation<ref>PMID:28181049</ref>. SMC exhibits the ability to super-coil DNA<ref>PMID:23218009</ref>. SMC of ''E. coli'' is named '''MukB''' or '''Chromosome partition protein A'''. '''MukE''' and '''MukF''' are associated with MukB. SMC is found in species from bacteria to human. SMC and cohesin which share structural similarities, are essential for separting the genome into daughter cells during cell division. SMC reorganizes chromsomes into their compact mitotic structure while cohesin glues replicated sister chromatids together until they split at anaphase<ref>PMID:12838344</ref>. |
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== Relevance == | == Relevance == | ||
Revision as of 09:16, 3 April 2020
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3D Structures of condensin
Updated on 03-April-2020
References
- ↑ Kalitsis P, Zhang T, Marshall KM, Nielsen CF, Hudson DF. Condensin, master organizer of the genome. Chromosome Res. 2017 Mar;25(1):61-76. doi: 10.1007/s10577-017-9553-0. Epub 2017, Feb 9. PMID:28181049 doi:http://dx.doi.org/10.1007/s10577-017-9553-0
- ↑ Thadani R, Uhlmann F, Heeger S. Condensin, chromatin crossbarring and chromosome condensation. Curr Biol. 2012 Dec 4;22(23):R1012-21. doi: 10.1016/j.cub.2012.10.023. PMID:23218009 doi:http://dx.doi.org/10.1016/j.cub.2012.10.023
- ↑ Hagstrom KA, Meyer BJ. Condensin and cohesin: more than chromosome compactor and glue. Nat Rev Genet. 2003 Jul;4(7):520-34. doi: 10.1038/nrg1110. PMID:12838344 doi:http://dx.doi.org/10.1038/nrg1110
- ↑ Zhao H, Petrushenko ZM, Walker JK, Baudry J, Zgurskaya HI, Rybenkov VV. Small Molecule Condensin Inhibitors. ACS Infect Dis. 2018 Dec 14;4(12):1737-1745. doi: 10.1021/acsinfecdis.8b00222., Epub 2018 Oct 22. PMID:30346684 doi:http://dx.doi.org/10.1021/acsinfecdis.8b00222
