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Condensin

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== Structural highlights ==
== Structural highlights ==
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SMC is a multisubunit complex. In vertebrates condensin complex is formed from the association of SMC2 and SMC4 subunits. SMC2 and SMC4 contain 3 domains: head domain forming anATPase, a long coiled-coil region and a hinge domain which facilitates SMC2/SMC4 dimerization.
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SMC is a multisubunit complex. In vertebrates condensin complex is formed from the association of SMC2 and SMC4 subunits. SMC2 and SMC4 contain 3 domains: head domain forming an ATPase, a long coiled-coil region and a hinge domain which facilitates SMC2/SMC4 dimerization.
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Current revision

Yeast SMC subunit 2 (green) and subunit 3 (grey) complex with DNA (PDB code 5oqn

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3D Structures of condensin

Updated on 04-April-2020

References

  1. ↑ Kalitsis P, Zhang T, Marshall KM, Nielsen CF, Hudson DF. Condensin, master organizer of the genome. Chromosome Res. 2017 Mar;25(1):61-76. doi: 10.1007/s10577-017-9553-0. Epub 2017, Feb 9. PMID:28181049 doi:http://dx.doi.org/10.1007/s10577-017-9553-0
  2. ↑ Thadani R, Uhlmann F, Heeger S. Condensin, chromatin crossbarring and chromosome condensation. Curr Biol. 2012 Dec 4;22(23):R1012-21. doi: 10.1016/j.cub.2012.10.023. PMID:23218009 doi:http://dx.doi.org/10.1016/j.cub.2012.10.023
  3. ↑ Hagstrom KA, Meyer BJ. Condensin and cohesin: more than chromosome compactor and glue. Nat Rev Genet. 2003 Jul;4(7):520-34. doi: 10.1038/nrg1110. PMID:12838344 doi:http://dx.doi.org/10.1038/nrg1110
  4. ↑ Zhao H, Petrushenko ZM, Walker JK, Baudry J, Zgurskaya HI, Rybenkov VV. Small Molecule Condensin Inhibitors. ACS Infect Dis. 2018 Dec 14;4(12):1737-1745. doi: 10.1021/acsinfecdis.8b00222., Epub 2018 Oct 22. PMID:30346684 doi:http://dx.doi.org/10.1021/acsinfecdis.8b00222

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Michal Harel

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