Sandbox Reserved 1606

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== Structural highlights ==
== Structural highlights ==
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===Overall 3D Structure===
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ABCG2 is a homodimer with each dimer containing two domains, the nucleotide binding domain (NBD) and the transmembrane domain. The NDB is located inside of the cell while the transmembrane domain is located in the cell membrane. [[Image:membrane domains.png|200 px|right|thumb|Figure 1. Domains of ABCG2 Multidrug transporter]]
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[[Image:membrane domains.png|200 px|right|thumb|FIGURE LEGEND]] NBD - binding site for atp Homodimer
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===ATP Bound and Unbound Conformations===
===ATP Bound and Unbound Conformations===
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As an [https://en.wikipedia.org/wiki/ATP-binding_cassette_transporter ABC Transporter], ABCG2 exhibits ATPase activity in which it binds and hydrolyzes ATP in order to cultivate the energy needed for the transport of molecules across the cell membrane. Two molecules of ATP bind the
<scene name='83/832932/Atp_bound_use/1'>ATP Bound</scene>
<scene name='83/832932/Atp_bound_use/1'>ATP Bound</scene>
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===Cavities and Leucine Plug===
===Cavities and Leucine Plug===
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[[Image:cavity 1,2 lysine plug.png|200 px|left|thumb|FIGURE LEGEND]]
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[[Image:Map_leucine_plug.png|200 px|left|thumb|Figure 2. Locations of Cavities 1 and 2 and the Leucine Plug in ABCG2.]]
<scene name='83/832932/Lysine_plug_use/1'>Leucine Plug</scene>
<scene name='83/832932/Lysine_plug_use/1'>Leucine Plug</scene>

Revision as of 15:19, 4 April 2020

This Sandbox is Reserved from Jan 13 through September 1, 2020 for use in the course CH462 Biochemistry II taught by R. Jeremy Johnson at the Butler University, Indianapolis, USA. This reservation includes Sandbox Reserved 1598 through Sandbox Reserved 1627.
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ABCG2 Multidrug Transporter

ABCG2 Multidrug Transporter

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References

[1] [2]

  1. ↑ 1.0 1.1 1.2 Taylor NMI, Manolaridis I, Jackson SM, Kowal J, Stahlberg H, Locher KP. Structure of the human multidrug transporter ABCG2. Nature. 2017 Jun 22;546(7659):504-509. doi: 10.1038/nature22345. Epub 2017 May, 29. PMID:28554189 doi:http://dx.doi.org/10.1038/nature22345
  2. ↑ 2.0 2.1 Manolaridis I, Jackson SM, Taylor NMI, Kowal J, Stahlberg H, Locher KP. Cryo-EM structures of a human ABCG2 mutant trapped in ATP-bound and substrate-bound states. Nature. 2018 Nov;563(7731):426-430. doi: 10.1038/s41586-018-0680-3. Epub 2018 Nov, 7. PMID:30405239 doi:http://dx.doi.org/10.1038/s41586-018-0680-3

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