1out
From Proteopedia
(New page: 200px<br /> <applet load="1out" size="450" color="white" frame="true" align="right" spinBox="true" caption="1out, resolution 2.3Å" /> '''TROUT HEMOGLOBIN I''...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:1out. | + | [[Image:1out.jpg|left|200px]]<br /><applet load="1out" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1out" size=" | + | |
caption="1out, resolution 2.3Å" /> | caption="1out, resolution 2.3Å" /> | ||
'''TROUT HEMOGLOBIN I'''<br /> | '''TROUT HEMOGLOBIN I'''<br /> | ||
| Line 8: | Line 7: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1OUT is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Oncorhynchus_mykiss Oncorhynchus mykiss] with ACE and HEM as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 1OUT is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Oncorhynchus_mykiss Oncorhynchus mykiss] with <scene name='pdbligand=ACE:'>ACE</scene> and <scene name='pdbligand=HEM:'>HEM</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OUT OCA]. |
==Reference== | ==Reference== | ||
| Line 23: | Line 22: | ||
[[Category: respiratory protein]] | [[Category: respiratory protein]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:36:12 2008'' |
Revision as of 14:36, 15 February 2008
|
TROUT HEMOGLOBIN I
Overview
We have determined the X-ray crystallographic structure of trout Hb I in, both the deoxy and carbonmonoxy forms to resolution limits of 2.3, angstroms and 2.5 angstroms, respectively. The overall fold of the, molecule is highly similar to that of human HbA despite the low level of, sequence identity between these proteins. Trout Hb I is unusual in, displaying almost no pH dependence of oxygen binding affinity, and (at, most) very weak interactions with heterotropic effector ligands such as, organic phosphates. Comparison of the two quaternary states of the protein, indicates how such effects are minimised and how the low-affinity T state, of the protein is stabilised in the absence of heterotropic interactions.
About this Structure
1OUT is a Protein complex structure of sequences from Oncorhynchus mykiss with and as ligands. Full crystallographic information is available from OCA.
Reference
The crystal structures of trout Hb I in the deoxy and carbonmonoxy forms., Tame JR, Wilson JC, Weber RE, J Mol Biol. 1996 Jun 21;259(4):749-60. PMID:8683580
Page seeded by OCA on Fri Feb 15 16:36:12 2008
