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1axt

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[[Image:1axt.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1axt| PDB=1axt | SCENE= }}
{{STRUCTURE_1axt| PDB=1axt | SCENE= }}
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'''IMMUNE VERSUS NATURAL SELECTION: ANTIBODY ALDOLASES WITH THE RATES OF NATURAL ENZYMES'''
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===IMMUNE VERSUS NATURAL SELECTION: ANTIBODY ALDOLASES WITH THE RATES OF NATURAL ENZYMES===
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==Overview==
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Structural and mechanistic studies show that when the selection criteria of the immune system are changed, catalytic antibodies that have the efficiency of natural enzymes evolve, but the catalytic antibodies are much more accepting of a wide range of substrates. The catalytic antibodies were prepared by reactive immunization, a process whereby the selection criteria of the immune system are changed from simple binding to chemical reactivity. This process yielded aldolase catalytic antibodies that approximated the rate acceleration of the natural enzyme used in glycolysis. Unlike the natural enzyme, however, the antibody aldolases catalyzed a variety of aldol reactions and decarboxylations. The crystal structure of one of these antibodies identified the reactive lysine residue that was selected in the immunization process. This lysine is deeply buried in a hydrophobic pocket at the base of the binding site, thereby accounting for its perturbed pKa.
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(as it appears on PubMed at http://www.pubmed.gov), where 9405338 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9405338}}
==About this Structure==
==About this Structure==
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[[Category: Catalyst]]
[[Category: Catalyst]]
[[Category: Immunoglobulin]]
[[Category: Immunoglobulin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:49:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:49:23 2008''

Revision as of 14:49, 30 June 2008

Image:1axt.png

Template:STRUCTURE 1axt

IMMUNE VERSUS NATURAL SELECTION: ANTIBODY ALDOLASES WITH THE RATES OF NATURAL ENZYMES

Template:ABSTRACT PUBMED 9405338

About this Structure

1AXT is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Immune versus natural selection: antibody aldolases with enzymic rates but broader scope., Barbas CF 3rd, Heine A, Zhong G, Hoffmann T, Gramatikova S, Bjornestedt R, List B, Anderson J, Stura EA, Wilson IA, Lerner RA, Science. 1997 Dec 19;278(5346):2085-92. PMID:9405338

Page seeded by OCA on Mon Jun 30 17:49:23 2008

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