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5dnm

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Current revision (21:51, 28 June 2023) (edit) (undo)
 
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<StructureSection load='5dnm' size='340' side='right'caption='[[5dnm]], [[Resolution|resolution]] 2.81&Aring;' scene=''>
<StructureSection load='5dnm' size='340' side='right'caption='[[5dnm]], [[Resolution|resolution]] 2.81&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5dnm]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DNM OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5DNM FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5dnm]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DNM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DNM FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=RAX:DICHLORO[(1,2,3,4,5,6-ETA)-6-METHYLBENZENE]1,3,5-TRIAZA-7LAMBDA~5~-PHOSPHATRICYCLO[3.3.1.1~3,7~]DEC-7-YLRUTHENIUM'>RAX</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.81&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5dnn|5dnn]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=RAX:DICHLORO[(1,2,3,4,5,6-ETA)-6-METHYLBENZENE]1,3,5-TRIAZA-7LAMBDA~5~-PHOSPHATRICYCLO[3.3.1.1~3,7~]DEC-7-YLRUTHENIUM'>RAX</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5dnm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dnm OCA], [http://pdbe.org/5dnm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dnm RCSB], [http://www.ebi.ac.uk/pdbsum/5dnm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5dnm ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5dnm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dnm OCA], [https://pdbe.org/5dnm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5dnm RCSB], [https://www.ebi.ac.uk/pdbsum/5dnm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5dnm ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/H2B11_XENLA H2B11_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [[http://www.uniprot.org/uniprot/H32_XENLA H32_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [[http://www.uniprot.org/uniprot/H4_XENLA H4_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
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[https://www.uniprot.org/uniprot/H4_XENLA H4_XENLA] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Adhireksan, Z]]
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[[Category: Synthetic construct]]
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[[Category: Davey, C A]]
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[[Category: Xenopus laevis]]
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[[Category: Muhammad, R]]
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[[Category: Adhireksan Z]]
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[[Category: Histone binding]]
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[[Category: Davey CA]]
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[[Category: Nucleosome]]
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[[Category: Muhammad R]]
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[[Category: Ruthenium antitumour compound]]
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[[Category: Structural protein-dna complex]]
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Current revision

Nucleosome core particle containing adducts of ruthenium(II)-toluene PTA complex

PDB ID 5dnm

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