Spike protein
From Proteopedia
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== Function == | == Function == | ||
| - | The viral '''spike protein''' (Spi) binds the virus to its host cell via the cell's receptor: angiotensin-converting enzyme 2 (ACE2). The trimeric 2019-nCoV Spi binds to ACE2 at least 10 times more tightly than SARS coronavirus. | + | The viral '''spike protein''' (Spi) binds the virus to its host cell via the cell's receptor: angiotensin-converting enzyme 2 (ACE2). The trimeric 2019-nCoV Spi binds to ACE2 at least 10 times more tightly than SARS coronavirus Spi. |
== Disease == | == Disease == | ||
| - | Numerous viral diseases are causing world-shattering consequences and the current pandemic CoVID-2019 is the recent one. | + | Numerous viral diseases are causing world-shattering consequences and the current pandemic of CoVID-2019 is the recent one. |
== Relevance == | == Relevance == | ||
| - | The spike protein is a key target for potential therapies and diagnostics. Various antibodies are currently being tested as potential antiviral treatment<ref>PMID:32065055</ref>. | + | The spike protein is a key target for potential therapies and diagnostics. Various antibodies are currently being tested as potential CoVID-2019 antiviral treatment<ref>PMID:32065055</ref>. |
== Structural highlights == | == Structural highlights == | ||
Revision as of 09:44, 8 April 2020
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3D Structures of spike protein
Updated on 08-April-2020
References
- ↑ Tian X, Li C, Huang A, Xia S, Lu S, Shi Z, Lu L, Jiang S, Yang Z, Wu Y, Ying T. Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody. Emerg Microbes Infect. 2020 Feb 17;9(1):382-385. doi:, 10.1080/22221751.2020.1729069. eCollection 2020. PMID:32065055 doi:http://dx.doi.org/10.1080/22221751.2020.1729069
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Michal Harel, Alexander Berchansky, Eric Martz, Joel L. Sussman
