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2xql

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<SX load='2xql' size='340' side='right' viewer='molstar' caption='[[2xql]], [[Resolution|resolution]] 19.50&Aring;' scene=''>
<SX load='2xql' size='340' side='right' viewer='molstar' caption='[[2xql]], [[Resolution|resolution]] 19.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2xql]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQL OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2XQL FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2xql]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XQL FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2hio|2hio]], [[1tzy|1tzy]], [[1hq3|1hq3]], [[2aro|2aro]], [[1hio|1hio]], [[1eqz|1eqz]]</td></tr>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2hio|2hio]], [[1tzy|1tzy]], [[1hq3|1hq3]], [[2aro|2aro]], [[1hio|1hio]], [[1eqz|1eqz]]</div></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2xql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xql OCA], [http://pdbe.org/2xql PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xql RCSB], [http://www.ebi.ac.uk/pdbsum/2xql PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xql ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xql OCA], [https://pdbe.org/2xql PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xql RCSB], [https://www.ebi.ac.uk/pdbsum/2xql PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xql ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/H2A4_CHICK H2A4_CHICK]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
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[[https://www.uniprot.org/uniprot/H2A4_CHICK H2A4_CHICK]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==

Revision as of 10:38, 12 January 2022

Fitting of the H2A-H2B histones in the electron microscopy map of the complex Nucleoplasmin:H2A-H2B histones (1:5).

2xql, resolution 19.50Å

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