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3j6u
From Proteopedia
(Difference between revisions)
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<SX load='3j6u' size='340' side='right' viewer='molstar' caption='[[3j6u]], [[Resolution|resolution]] 9.00Å' scene=''> | <SX load='3j6u' size='340' side='right' viewer='molstar' caption='[[3j6u]], [[Resolution|resolution]] 9.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3j6u]] is a 8 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3j6u]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_3 Dengue virus 3] and [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J6U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3J6U FirstGlance]. <br> |
| - | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3j6s|3j6s]], [[3j6t|3j6t]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3j6s|3j6s]], [[3j6t|3j6t]]</div></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3j6u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j6u OCA], [https://pdbe.org/3j6u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3j6u RCSB], [https://www.ebi.ac.uk/pdbsum/3j6u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3j6u ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/Q6DLV0_9FLAV Q6DLV0_9FLAV]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS000336_004_099774] |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Revision as of 03:51, 21 April 2022
Cryo-EM structure of Dengue virus serotype 3 in complex with human antibody 5J7 Fab
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