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5fkw

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Current revision (06:55, 19 July 2023) (edit) (undo)
 
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<SX load='5fkw' size='340' side='right' viewer='molstar' caption='[[5fkw]], [[Resolution|resolution]] 7.30&Aring;' scene=''>
<SX load='5fkw' size='340' side='right' viewer='molstar' caption='[[5fkw]], [[Resolution|resolution]] 7.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5fkw]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FKW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5FKW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5fkw]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FKW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FKW FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5fku|5fku]], [[5fkv|5fkv]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 7.3&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fkw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fkw OCA], [https://pdbe.org/5fkw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fkw RCSB], [https://www.ebi.ac.uk/pdbsum/5fkw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fkw ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5fkw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fkw OCA], [http://pdbe.org/5fkw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fkw RCSB], [http://www.ebi.ac.uk/pdbsum/5fkw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fkw ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DPO3A_ECOLI DPO3A_ECOLI]] DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase. [[http://www.uniprot.org/uniprot/DPO3E_ECOLI DPO3E_ECOLI]] DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease. [[http://www.uniprot.org/uniprot/DPO3B_ECOLI DPO3B_ECOLI]] DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP-independent) along duplex DNA.
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[https://www.uniprot.org/uniprot/DPO3A_ECOLI DPO3A_ECOLI] DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</SX>
</SX>
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[[Category: DNA-directed DNA polymerase]]
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[[Category: Escherichia coli K-12]]
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[[Category: Ecoli]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Conrad, J]]
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[[Category: Synthetic construct]]
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[[Category: Fernandez-Leiro, R]]
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[[Category: Conrad J]]
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[[Category: Lamers, M H]]
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[[Category: Fernandez-Leiro R]]
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[[Category: Scheres, S H.W]]
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[[Category: Lamers MH]]
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[[Category: Dna polymerase iii alpha]]
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[[Category: Scheres SHW]]
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[[Category: Dna polymerase iii beta]]
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[[Category: Dna polymerase iii epsilon]]
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[[Category: Dna replication]]
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[[Category: Transferase]]
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Current revision

cryo-EM structure of the E. coli replicative DNA polymerase complex bound to DNA (DNA polymerase III alpha, beta, epsilon)

5fkw, resolution 7.30Å

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