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5hnx

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<SX load='5hnx' size='340' side='right' viewer='molstar' caption='[[5hnx]], [[Resolution|resolution]] 6.60&Aring;' scene=''>
<SX load='5hnx' size='340' side='right' viewer='molstar' caption='[[5hnx]], [[Resolution|resolution]] 6.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5hnx]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HNX OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5HNX FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5hnx]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HNX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HNX FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TA1:TAXOL'>TA1</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 6.6&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5hnw|5hnw]], [[5hny|5hny]], [[5hnz|5hnz]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TA1:TAXOL'>TA1</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ncd ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hnx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hnx OCA], [https://pdbe.org/5hnx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hnx RCSB], [https://www.ebi.ac.uk/pdbsum/5hnx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hnx ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5hnx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hnx OCA], [http://pdbe.org/5hnx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hnx RCSB], [http://www.ebi.ac.uk/pdbsum/5hnx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hnx ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TBA1B_BOVIN TBA1B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [[http://www.uniprot.org/uniprot/NCD_DROME NCD_DROME]] NCD is required for normal chromosomal segregation in meiosis, in females, and in early mitotic divisions of the embryo. The NCD motor activity is directed toward the microtubule's minus end.<ref>PMID:2146510</ref> [[http://www.uniprot.org/uniprot/TBB2B_BOVIN TBB2B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).
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[https://www.uniprot.org/uniprot/TBA1B_BOVIN TBA1B_BOVIN] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</SX>
</SX>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Drome]]
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[[Category: Drosophila melanogaster]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Kikkawa, M]]
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[[Category: Rattus norvegicus]]
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[[Category: Nitta, R]]
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[[Category: Kikkawa M]]
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[[Category: Shigematsu, H]]
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[[Category: Nitta R]]
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[[Category: Shirouzu, M]]
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[[Category: Shigematsu H]]
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[[Category: Yokoyama, T]]
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[[Category: Shirouzu M]]
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[[Category: Atpase]]
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[[Category: Yokoyama T]]
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[[Category: Kinesin]]
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[[Category: Kinesin-14]]
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[[Category: Microtubule]]
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[[Category: Structural protein-motor protein complex]]
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Revision as of 10:48, 16 August 2023

Structural basis of backwards motion in kinesin-14: minus-end directed nKn664 in the nucleotide-free state

5hnx, resolution 6.60Å

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