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5ij9

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<SX load='5ij9' size='340' side='right' viewer='molstar' caption='[[5ij9]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
<SX load='5ij9' size='340' side='right' viewer='molstar' caption='[[5ij9]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5ij9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IJ9 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5IJ9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5ij9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IJ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IJ9 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.7&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ij0|5ij0]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TUBA1B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), TUBB3, TUBB4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ij9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ij9 OCA], [https://pdbe.org/5ij9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ij9 RCSB], [https://www.ebi.ac.uk/pdbsum/5ij9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ij9 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5ij9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ij9 OCA], [http://pdbe.org/5ij9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ij9 RCSB], [http://www.ebi.ac.uk/pdbsum/5ij9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ij9 ProSAT]</span></td></tr>
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</table>
</table>
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== Disease ==
 
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[[http://www.uniprot.org/uniprot/TBB3_HUMAN TBB3_HUMAN]] Congenital fibrosis of extraocular muscles;Cortical dysgenesis with pontocerebellar hypoplasia due to TUBB3 mutation. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
 
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TBA1B_HUMAN TBA1B_HUMAN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [[http://www.uniprot.org/uniprot/TBB3_HUMAN TBB3_HUMAN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. TUBB3 plays a critical role in proper axon guidance and mantainance.<ref>PMID:20074521</ref>
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[https://www.uniprot.org/uniprot/TBA1B_HUMAN TBA1B_HUMAN] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</SX>
</SX>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Cade, N I]]
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[[Category: Cade NI]]
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[[Category: Duellberg, C]]
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[[Category: Duellberg C]]
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[[Category: Forth, S]]
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[[Category: Forth S]]
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[[Category: Howes, S C]]
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[[Category: Howes SC]]
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[[Category: Kapoor, T M]]
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[[Category: Kapoor TM]]
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[[Category: Kleiner, R E]]
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[[Category: Kleiner RE]]
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[[Category: Nogales, E]]
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[[Category: Nogales E]]
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[[Category: Pamula, M C]]
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[[Category: Pamula MC]]
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[[Category: Surrey, T]]
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[[Category: Surrey T]]
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[[Category: Ti, S C]]
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[[Category: Ti SC]]
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[[Category: Hydrolysis]]
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[[Category: Microtubule]]
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[[Category: Mutant tubulin]]
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[[Category: Structural protein]]
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Revision as of 13:56, 30 August 2023

Cryo EM density of microtubule assembled from human TUBB3-D417H mutant

5ij9, resolution 3.70Å

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