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| | <SX load='5osg' size='340' side='right' viewer='molstar' caption='[[5osg]], [[Resolution|resolution]] 2.90Å' scene=''> | | <SX load='5osg' size='340' side='right' viewer='molstar' caption='[[5osg]], [[Resolution|resolution]] 2.90Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[5osg]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Leido Leido]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OSG OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5OSG FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5osg]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_donovani Leishmania donovani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OSG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5OSG FirstGlance]. <br> |
| - | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5t2a|5t2a]]</td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.9Å</td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LDBPK_320790 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5661 LEIDO]), RPS6, L3640.11, Lmj_1130, LmjF21.1780, LmjF_21_1780 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5661 LEIDO])</td></tr>
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5osg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5osg OCA], [https://pdbe.org/5osg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5osg RCSB], [https://www.ebi.ac.uk/pdbsum/5osg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5osg ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5osg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5osg OCA], [http://pdbe.org/5osg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5osg RCSB], [http://www.ebi.ac.uk/pdbsum/5osg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5osg ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/RS6_LEIMA RS6_LEIMA]] May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA. | + | [https://www.uniprot.org/uniprot/A0A3Q8IT45_LEIDO A0A3Q8IT45_LEIDO] |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | </SX> | | </SX> |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Leido]] | + | [[Category: Leishmania donovani]] |
| - | [[Category: Bochler, A]] | + | [[Category: Bochler A]] |
| - | [[Category: Chicher, J]] | + | [[Category: Brito Querido J]] |
| - | [[Category: Hashem, Y]] | + | [[Category: Chicher J]] |
| - | [[Category: Mancera-Martinez, E]] | + | [[Category: Hashem Y]] |
| - | [[Category: Querido, J Brito]]
| + | [[Category: Mancera-Martinez E]] |
| - | [[Category: Simonetti, A]] | + | [[Category: Simonetti A]] |
| - | [[Category: Vicens, Q]] | + | [[Category: Vicens Q]] |
| - | [[Category: Cryo-em]]
| + | |
| - | [[Category: Kinetoplastid]]
| + | |
| - | [[Category: Ksrp]]
| + | |
| - | [[Category: Ribosome]]
| + | |
| Structural highlights
Function
A0A3Q8IT45_LEIDO
Publication Abstract from PubMed
Kinetoplastids are potentially lethal protozoan pathogens affecting more than 20 million people worldwide. There is a critical need for more specific targets for the development of safer anti-kinetoplastid therapeutic molecules that can replace the scarce and highly cytotoxic current drugs. The kinetoplastid ribosome represents a potential therapeutic target due to its relative structural divergence when compared with its human counterpart. However, several kinetoplastid-specific ribosomal features remain uncharacterized. Here, we present the near-atomic cryoelectron microscopy structure of a novel bona fide kinetoplastid-specific ribosomal (r-) protein (KSRP) bound to the ribosome. KSRP is an essential protein located at the solvent face of the 40S subunit, where it binds and stabilizes kinetoplastid-specific domains of rRNA, suggesting its role in ribosome integrity. KSRP also interacts with the r-protein eS6 at a region that is only conserved in kinetoplastids. The kinetoplastid-specific ribosomal environment of KSRP provides a promising target for the design of safer anti-kinetoplastidian drugs.
The cryo-EM Structure of a Novel 40S Kinetoplastid-Specific Ribosomal Protein.,Brito Querido J, Mancera-Martinez E, Vicens Q, Bochler A, Chicher J, Simonetti A, Hashem Y Structure. 2017 Oct 13. pii: S0969-2126(17)30305-2. doi:, 10.1016/j.str.2017.09.014. PMID:29107485[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Brito Querido J, Mancera-Martinez E, Vicens Q, Bochler A, Chicher J, Simonetti A, Hashem Y. The cryo-EM Structure of a Novel 40S Kinetoplastid-Specific Ribosomal Protein. Structure. 2017 Oct 13. pii: S0969-2126(17)30305-2. doi:, 10.1016/j.str.2017.09.014. PMID:29107485 doi:http://dx.doi.org/10.1016/j.str.2017.09.014
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