5t5h

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<SX load='5t5h' size='340' side='right' viewer='molstar' caption='[[5t5h]], [[Resolution|resolution]] 2.54&Aring;' scene=''>
<SX load='5t5h' size='340' side='right' viewer='molstar' caption='[[5t5h]], [[Resolution|resolution]] 2.54&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5t5h]] is a 46 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T5H OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5T5H FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5t5h]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T5H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5T5H FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.54&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5MC:5-METHYLCYTIDINE-5-MONOPHOSPHATE'>5MC</scene>, <scene name='pdbligand=7MG:7N-METHYL-8-HYDROGUANOSINE-5-MONOPHOSPHATE'>7MG</scene>, <scene name='pdbligand=A2M:2-O-METHYLADENOSINE+5-(DIHYDROGEN+PHOSPHATE)'>A2M</scene>, <scene name='pdbligand=OMC:O2-METHYLYCYTIDINE-5-MONOPHOSPHATE'>OMC</scene>, <scene name='pdbligand=OMG:O2-METHYLGUANOSINE-5-MONOPHOSPHATE'>OMG</scene>, <scene name='pdbligand=OMU:O2-METHYLURIDINE+5-MONOPHOSPHATE'>OMU</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5MC:5-METHYLCYTIDINE-5-MONOPHOSPHATE'>5MC</scene>, <scene name='pdbligand=7MG:7N-METHYL-8-HYDROGUANOSINE-5-MONOPHOSPHATE'>7MG</scene>, <scene name='pdbligand=A2M:2-O-METHYLADENOSINE+5-(DIHYDROGEN+PHOSPHATE)'>A2M</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=OMC:O2-METHYLYCYTIDINE-5-MONOPHOSPHATE'>OMC</scene>, <scene name='pdbligand=OMG:O2-METHYLGUANOSINE-5-MONOPHOSPHATE'>OMG</scene>, <scene name='pdbligand=OMU:O2-METHYLURIDINE+5-MONOPHOSPHATE'>OMU</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5t5h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t5h OCA], [http://pdbe.org/5t5h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5t5h RCSB], [http://www.ebi.ac.uk/pdbsum/5t5h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5t5h ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5t5h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t5h OCA], [https://pdbe.org/5t5h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5t5h RCSB], [https://www.ebi.ac.uk/pdbsum/5t5h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5t5h ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/Q4DXW6_TRYCC Q4DXW6_TRYCC]] Binds to the 23S rRNA.[RuleBase:RU000576]
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[https://www.uniprot.org/uniprot/RL18_TRYCC RL18_TRYCC]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Ribosomes of trypanosomatids, a family of protozoan parasites causing debilitating human diseases, possess multiply fragmented rRNAs that together are analogous to 28S rRNA, unusually large rRNA expansion segments, and r-protein variations compared with other eukaryotic ribosomes. To investigate the architecture of the trypanosomatid ribosomes, we determined the 2.5-A structure of the Trypanosoma cruzi ribosome large subunit by single-particle cryo-EM. Examination of this structure and comparative analysis of the yeast ribosomal assembly pathway allowed us to develop a stepwise assembly model for the eight pieces of the large subunit rRNAs and a number of ancillary "glue" proteins. This model can be applied to the characterization of Trypanosoma brucei and Leishmania spp. ribosomes as well. Together with other details, our atomic-level structure may provide a foundation for structure-based design of antitrypanosome drugs.
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Structure and assembly model for the Trypanosoma cruzi 60S ribosomal subunit.,Liu Z, Gutierrez-Vargas C, Wei J, Grassucci RA, Ramesh M, Espina N, Sun M, Tutuncuoglu B, Madison-Antenucci S, Woolford JL Jr, Tong L, Frank J Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):12174-12179. Epub 2016 Oct 10. PMID:27791004<ref>PMID:27791004</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 5t5h" style="background-color:#fffaf0;"></div>
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==See Also==
==See Also==
*[[Ribosome 3D structures|Ribosome 3D structures]]
*[[Ribosome 3D structures|Ribosome 3D structures]]
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== References ==
 
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<references/>
 
__TOC__
__TOC__
</SX>
</SX>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Trypanosoma cruzi]]
[[Category: Trypanosoma cruzi]]
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[[Category: Espina, N]]
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[[Category: Espina N]]
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[[Category: Frank, J]]
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[[Category: Frank J]]
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[[Category: Grassucci, R A]]
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[[Category: Grassucci RA]]
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[[Category: Gutierrez-Vargas, C]]
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[[Category: Gutierrez-Vargas C]]
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[[Category: Liu, Z]]
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[[Category: Liu Z]]
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[[Category: Madison-Antenucci, S]]
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[[Category: Madison-Antenucci S]]
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[[Category: Ramesh, M]]
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[[Category: Ramesh M]]
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[[Category: Sun, M]]
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[[Category: Sun M]]
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[[Category: Tong, L]]
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[[Category: Tong L]]
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[[Category: Tutuncuoglu, B]]
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[[Category: Tutuncuoglu B]]
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[[Category: Wei, J]]
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[[Category: Wei J]]
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[[Category: Woolford, J L]]
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[[Category: Woolford Jr JL]]
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[[Category: 5 angstrom cryo-em structure]]
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[[Category: Assmebly]]
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[[Category: Multiply fragmented rrna]]
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[[Category: Ribosomal subunit]]
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[[Category: Ribosome]]
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Revision as of 15:36, 6 March 2024

Structure and assembly model for the Trypanosoma cruzi 60S ribosomal subunit

5t5h, resolution 2.54Å

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OCA

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