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5z96

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Current revision (08:54, 9 October 2024) (edit) (undo)
 
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<SX load='5z96' size='340' side='right' viewer='molstar' caption='[[5z96]], [[Resolution|resolution]] 3.28&Aring;' scene=''>
<SX load='5z96' size='340' side='right' viewer='molstar' caption='[[5z96]], [[Resolution|resolution]] 3.28&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5z96]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z96 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5Z96 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5z96]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z96 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5Z96 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LPP:2-(HEXADECANOYLOXY)-1-[(PHOSPHONOOXY)METHYL]ETHYL+HEXADECANOATE'>LPP</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.28&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Trpc4, Trrp4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LPP:2-(HEXADECANOYLOXY)-1-[(PHOSPHONOOXY)METHYL]ETHYL+HEXADECANOATE'>LPP</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5z96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z96 OCA], [http://pdbe.org/5z96 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5z96 RCSB], [http://www.ebi.ac.uk/pdbsum/5z96 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5z96 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5z96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z96 OCA], [https://pdbe.org/5z96 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5z96 RCSB], [https://www.ebi.ac.uk/pdbsum/5z96 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5z96 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TRPC4_MOUSE TRPC4_MOUSE]] Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion. Trpc4 deficient mice lack a store-operated calcium entry in endothelial cells.<ref>PMID:11175743</ref>
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[https://www.uniprot.org/uniprot/TRPC4_MOUSE TRPC4_MOUSE] Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion. Trpc4 deficient mice lack a store-operated calcium entry in endothelial cells.<ref>PMID:11175743</ref>
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: Duan, J]]
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[[Category: Duan J]]
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[[Category: Li, J]]
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[[Category: Li J]]
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[[Category: Li, Z]]
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[[Category: Li Z]]
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[[Category: Zhang, J]]
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[[Category: Zhang J]]
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[[Category: Cryoem]]
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[[Category: Membrane protein]]
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[[Category: Mouse full length trpc4]]
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Current revision

Structure of the mouse TRPC4 ion channel

5z96, resolution 3.28Å

Proteopedia Page Contributors and Editors (what is this?)

OCA

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