6bqw

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Current revision (14:23, 13 March 2024) (edit) (undo)
 
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<SX load='6bqw' size='340' side='right' viewer='molstar' caption='[[6bqw]], [[Resolution|resolution]] 4.20&Aring;' scene=''>
<SX load='6bqw' size='340' side='right' viewer='molstar' caption='[[6bqw]], [[Resolution|resolution]] 4.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6bqw]] is a 9 chain structure with sequence from [http://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BQW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6BQW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6bqw]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BQW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BQW FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6bqw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bqw OCA], [http://pdbe.org/6bqw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bqw RCSB], [http://www.ebi.ac.uk/pdbsum/6bqw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bqw ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bqw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bqw OCA], [https://pdbe.org/6bqw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bqw RCSB], [https://www.ebi.ac.uk/pdbsum/6bqw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bqw ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/O52947_BACIU O52947_BACIU]
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Bacterial actins are an evolutionarily diverse family of ATP-dependent filaments built from protomers with a conserved structural fold. Actin-based segregation systems are encoded on many bacterial plasmids and function to partition plasmids into daughter cells. The bacterial actin AlfA segregates plasmids by a mechanism distinct from other partition systems, dependent on its unique dynamic properties. Here, we report the near-atomic resolution electron cryo-microscopy structure of the AlfA filament, which reveals a strikingly divergent filament architecture resulting from the loss of a subdomain conserved in all other actins and a mode of ATP binding. Its unusual assembly interfaces and nucleotide interactions provide insight into AlfA dynamics, and expand the range of evolutionary variation accessible to actin quaternary structure.
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Cryo-EM structure of the bacterial actin AlfA reveals unique assembly and ATP-binding interactions and the absence of a conserved subdomain.,Usluer GD, DiMaio F, Yang SK, Hansen JM, Polka JK, Mullins RD, Kollman JM Proc Natl Acad Sci U S A. 2018 Feb 13. pii: 1715836115. doi:, 10.1073/pnas.1715836115. PMID:29440491<ref>PMID:29440491</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 6bqw" style="background-color:#fffaf0;"></div>
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==See Also==
==See Also==
*[[Actin 3D structures|Actin 3D structures]]
*[[Actin 3D structures|Actin 3D structures]]
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== References ==
 
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<references/>
 
__TOC__
__TOC__
</SX>
</SX>
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[[Category: Vibrio subtilis ehrenberg 1835]]
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[[Category: Bacillus subtilis]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: DiMaio, F]]
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[[Category: DiMaio F]]
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[[Category: Kollman, J M]]
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[[Category: Kollman JM]]
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[[Category: Usluer, G D]]
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[[Category: Usluer GD]]
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[[Category: Actin]]
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[[Category: Cytosolic protein]]
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[[Category: Filament]]
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[[Category: Plasmid segregation]]
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Current revision

AlfA Filament bound to AMPPNP

6bqw, resolution 4.20Å

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