|
|
| Line 3: |
Line 3: |
| | <SX load='6c70' size='340' side='right' viewer='molstar' caption='[[6c70]], [[Resolution|resolution]] 3.50Å' scene=''> | | <SX load='6c70' size='340' side='right' viewer='molstar' caption='[[6c70]], [[Resolution|resolution]] 3.50Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[6c70]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Apoba Apoba]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C70 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6C70 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6c70]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Apocrypta_bakeri Apocrypta bakeri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C70 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6C70 FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Or2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=490712 APOBA])</td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.5Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6c70 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c70 OCA], [http://pdbe.org/6c70 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6c70 RCSB], [http://www.ebi.ac.uk/pdbsum/6c70 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6c70 ProSAT]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6c70 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c70 OCA], [https://pdbe.org/6c70 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6c70 RCSB], [https://www.ebi.ac.uk/pdbsum/6c70 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6c70 ProSAT]</span></td></tr> |
| | </table> | | </table> |
| - | <div style="background-color:#fffaf0;">
| + | == Function == |
| - | == Publication Abstract from PubMed == | + | [https://www.uniprot.org/uniprot/B0FAQ4_APOBA B0FAQ4_APOBA] |
| - | The olfactory system must recognize and discriminate amongst an enormous variety of chemicals in the environment. To contend with such diversity, insects have evolved a family of odorant-gated ion channels comprised of a highly conserved co-receptor (Orco) and a divergent odorant receptor (OR) that confers chemical specificity. Here, we present the single-particle cryo-electron microscopy structure of an Orco homomer from the parasitic fig wasp Apocrypta bakeri at 3.5 A resolution, providing structural insight into this receptor family. Orco possesses a novel channel architecture, with four subunits symmetrically arranged around a central pore that diverges into four lateral conduits that open to the cytosol. The Orco tetramer has few inter-subunit interactions within the membrane and is bound together by a small cytoplasmic anchor domain. The minimal sequence conservation among ORs maps largely to the pore and anchor domain, shedding light on how the architecture of this receptor family accommodates its remarkable sequence diversity and facilitates the evolution of odour tuning.
| + | |
| - | | + | |
| - | Cryo-EM structure of the insect olfactory receptor Orco.,Butterwick JA, Del Marmol J, Kim KH, Kahlson MA, Rogow JA, Walz T, Ruta V Nature. 2018 Aug;560(7719):447-452. doi: 10.1038/s41586-018-0420-8. Epub 2018 Aug, 15. PMID:30111839<ref>PMID:30111839</ref>
| + | |
| - | | + | |
| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
| + | |
| - | </div>
| + | |
| - | <div class="pdbe-citations 6c70" style="background-color:#fffaf0;"></div>
| + | |
| - | == References ==
| + | |
| - | <references/>
| + | |
| | __TOC__ | | __TOC__ |
| | </SX> | | </SX> |
| - | [[Category: Apoba]] | + | [[Category: Apocrypta bakeri]] |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Butterwick, J A]] | + | [[Category: Butterwick JA]] |
| - | [[Category: Kim, K H]] | + | [[Category: Kim KH]] |
| - | [[Category: Ruta, V]] | + | [[Category: Ruta V]] |
| - | [[Category: Walz, T]] | + | [[Category: Walz T]] |
| - | [[Category: Fab]]
| + | |
| - | [[Category: Insect]]
| + | |
| - | [[Category: Ion channel]]
| + | |
| - | [[Category: Membrane protein]]
| + | |
| - | [[Category: Olfactory receptor]]
| + | |
