6drk

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Current revision (09:50, 23 October 2024) (edit) (undo)
 
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<SX load='6drk' size='340' side='right' viewer='molstar' caption='[[6drk]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
<SX load='6drk' size='340' side='right' viewer='molstar' caption='[[6drk]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6drk]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DRK OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6DRK FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6drk]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DRK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DRK FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">trpm2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Brachidanio rerio])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6drk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6drk OCA], [http://pdbe.org/6drk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6drk RCSB], [http://www.ebi.ac.uk/pdbsum/6drk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6drk ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6drk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6drk OCA], [https://pdbe.org/6drk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6drk RCSB], [https://www.ebi.ac.uk/pdbsum/6drk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6drk ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TRPM2_DANRE TRPM2_DANRE] Nonselective, voltage-independent cation channel that mediates Ca(2+) influx, leading to increased cytoplasmic Ca(2+) levels. Functions as a ligand-gated ion channel. Binding of ADP-ribose to the cytoplasmic N-terminal region causes a conformation change; the channel is primed but still requires Ca(2+) binding to trigger channel opening.<ref>PMID:30250252</ref>
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
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[[Category: Brachidanio rerio]]
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[[Category: Danio rerio]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Du, J]]
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[[Category: Du J]]
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[[Category: Huang, Y]]
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[[Category: Huang Y]]
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[[Category: Lu, W]]
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[[Category: Lu W]]
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[[Category: Sun, W]]
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[[Category: Sun W]]
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[[Category: Winkler, P]]
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[[Category: Winkler P]]
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[[Category: Transport protein]]
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Current revision

Structure of TRPM2 ion channel receptor by single particle electron cryo-microscopy, Apo state

6drk, resolution 3.80Å

Proteopedia Page Contributors and Editors (what is this?)

OCA

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